针对感染小鼠肝炎病毒的细胞的细胞毒性T细胞克隆的建立。
Establishment of cytotoxic T-cell clones specific for cells infected with mouse hepatitis virus.
作者信息
Yamaguchi K, Kyuwa S, Nakanaga K, Hayami M
机构信息
Department of Animal Pathology, University of Tokyo, Japan.
出版信息
J Virol. 1988 Jul;62(7):2505-7. doi: 10.1128/JVI.62.7.2505-2507.1988.
Abstract
Mouse hepatitis virus (MHV)-specific T-lymphocyte clones were established from MHV-infected BALB/c mice. They expressed Thy1 and Lyt2 antigens but lacked L3T4 and NK1 antigens. The clones killed MHV-infected but not uninfected or influenza virus-infected J774.1 cells. The specificity was further defined by a cold-target competition test.
摘要
从小鼠肝炎病毒（MHV）感染的BALB/c小鼠中建立了MHV特异性T淋巴细胞克隆。它们表达Thy1和Lyt2抗原，但缺乏L3T4和NK1抗原。这些克隆可杀死被MHV感染的J774.1细胞，但不能杀死未感染或被流感病毒感染的J774.1细胞。通过冷靶竞争试验进一步确定了其特异性。
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