感染小鼠肝炎病毒JHM株期间脑浸润单核细胞的特征分析
Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM.
作者信息
Williamson J S, Sykes K C, Stohlman S A
机构信息
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
出版信息
J Neuroimmunol. 1991 Jun;32(3):199-207. doi: 10.1016/0165-5728(91)90189-e.
Abstract
The eradication of infectious virus from the central nervous system (CNS) following infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) is thought to be immune-mediated. Furthermore, a significant decrease of infectious virus coincides with the appearance of prominent inflammatory infiltrates in the brain and spinal cord. In the present study, mononuclear cells infiltrating the brain during JHMV infection were isolated and characterized. While all subsets of immune cells were present, there appeared to be a temporal relationship between the peak incidence of CD8+ T cells (40% of total isolated cells) and reduction of virus at day 7 post-infection. Cells with the natural killer (NK) phenotype (at least 30%) were also present throughout infection. These data suggest that CD8+ T cells and NK cells are prominent among cells which infiltrate the brain during JHM virus infection and may have important roles in reduction of virus within the CNS.
摘要
感染嗜神经小鼠肝炎病毒（JHMV）的JHM株后，从中枢神经系统（CNS）清除传染性病毒被认为是免疫介导的。此外，传染性病毒的显著减少与脑和脊髓中明显的炎性浸润的出现同时发生。在本研究中，对JHMV感染期间浸润大脑的单核细胞进行了分离和鉴定。虽然存在所有免疫细胞亚群，但在感染后第7天，CD8 + T细胞的峰值发生率（占分离细胞总数的40%）与病毒减少之间似乎存在时间关系。具有自然杀伤（NK）表型的细胞（至少30%）在整个感染过程中也都存在。这些数据表明，CD8 + T细胞和NK细胞在JHM病毒感染期间浸润大脑的细胞中占突出地位，并且可能在中枢神经系统内病毒的减少中发挥重要作用。
相似文献
1
Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM.感染小鼠肝炎病毒JHM株期间脑浸润单核细胞的特征分析
J Neuroimmunol. 1991 Jun;32(3):199-207. doi: 10.1016/0165-5728(91)90189-e.
2
3
Induction of natural killer cells and interferon during mouse hepatitis virus infection of resistant and susceptible inbred mouse strains.在抗性和易感近交系小鼠感染小鼠肝炎病毒期间自然杀伤细胞和干扰素的诱导
Immunobiology. 1984 Jan;166(1):35-44. doi: 10.1016/S0171-2985(84)80141-2.
4
Characterization of T cells expanded in vivo during primary mouse hepatitis virus infection in mice.小鼠原发性肝炎病毒感染期间体内扩增的T细胞的特征分析
J Vet Med Sci. 1996 May;58(5):431-7. doi: 10.1292/jvms.58.431.
5
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.在嗜神经性小鼠肝炎病毒感染中枢神经系统后，CD4 T细胞有助于病毒控制和病理变化。
J Virol. 2008 Mar;82(5):2130-9. doi: 10.1128/JVI.01762-07. Epub 2007 Dec 19.
6
Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection.在JHM病毒感染期间，中枢神经系统中的迟发型超敏反应需要病毒特异性来提供保护。
J Neuroimmunol. 1988 Sep;19(3):255-68. doi: 10.1016/0165-5728(88)90007-0.
7
Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis.在病毒诱导的脑炎过程中，中性粒细胞促进单核细胞浸润。
J Immunol. 2003 Mar 15;170(6):3331-6. doi: 10.4049/jimmunol.170.6.3331.
8
Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis.淋巴细胞性脉络丛脑膜炎病毒引起的小鼠肝炎。II. 发病机制中涉及的细胞。
Lab Invest. 1995 May;72(5):559-70.
9
Phenotypic and functional characterization of CD8+ T lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis.
J Neurovirol. 1995 Dec;1(5-6):340-8. doi: 10.3109/13550289509111023.
10
Natural killer cell activity during mouse hepatitis virus infection: response in the absence of interferon.小鼠肝炎病毒感染期间的自然杀伤细胞活性：在无干扰素情况下的反应
Int J Cancer. 1983 Mar 15;31(3):309-14. doi: 10.1002/ijc.2910310310.
引用本文的文献
1
Immune responses to human respiratory coronaviruses infection in mouse models.人类呼吸道冠状病毒感染的小鼠模型中的免疫反应。
Curr Opin Virol. 2022 Feb;52:102-111. doi: 10.1016/j.coviro.2021.11.015. Epub 2021 Dec 11.
2
Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?多发性硬化症中神经炎症与神经退行性变的关联：少突胶质前体细胞是疾病的关键环节吗？
Front Cell Neurosci. 2021 Jun 21;15:654284. doi: 10.3389/fncel.2021.654284. eCollection 2021.
3
Viral mouse models used to study multiple sclerosis: past and present.用于研究多发性硬化症的病毒小鼠模型：过去和现在。
Arch Virol. 2021 Apr;166(4):1015-1033. doi: 10.1007/s00705-021-04968-5. Epub 2021 Feb 13.
4
Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis.趋化因子受体作为虫媒病毒性脑炎发病机制中的重要调节剂。
Front Cell Neurosci. 2014 Sep 30;8:264. doi: 10.3389/fncel.2014.00264. eCollection 2014.
5
Coronavirus pathogenesis.冠状病毒发病机制。
Adv Virus Res. 2011;81:85-164. doi: 10.1016/B978-0-12-385885-6.00009-2.
6
Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis.高活性细胞毒性 CD8 T 细胞在冠状病毒诱导的脑炎高峰期表达保护性的白细胞介素 10。
J Immunol. 2011 Mar 15;186(6):3642-52. doi: 10.4049/jimmunol.1003292. Epub 2011 Feb 11.
7
Cell replacement therapies to promote remyelination in a viral model of demyelination.细胞替代疗法促进脱髓鞘病毒模型中的髓鞘再生。
J Neuroimmunol. 2010 Jul 27;224(1-2):101-7. doi: 10.1016/j.jneuroim.2010.05.013. Epub 2010 Jun 2.
8
Pathogenesis of murine coronavirus in the central nervous system.鼠冠状病毒在中枢神经系统中的发病机制。
J Neuroimmune Pharmacol. 2010 Sep;5(3):336-54. doi: 10.1007/s11481-010-9202-2. Epub 2010 Apr 6.
9
Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.对1型小鼠肝炎病毒免疫反应的保护和病理作用：对严重急性呼吸综合征的启示
J Virol. 2009 Sep;83(18):9258-72. doi: 10.1128/JVI.00355-09. Epub 2009 Jul 1.
10
NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.NKG2D受体信号传导增强病毒特异性CD8 + T细胞的细胞溶解活性：在病毒诱导的脑炎中起保护作用的证据。
J Virol. 2008 Mar;82(6):3031-44. doi: 10.1128/JVI.02033-07. Epub 2007 Dec 26.
本文引用的文献
1
2
A glycolipid on the surface of mouse natural killer cells.小鼠自然杀伤细胞表面的一种糖脂。
Eur J Immunol. 1980 Mar;10(3):175-80. doi: 10.1002/eji.1830100304.
3
Establishment of monoclonal anti-Nk-1.1 antibody.抗Nk-1.1单克隆抗体的制备
Hybridoma. 1984 Fall;3(3):301-3. doi: 10.1089/hyb.1984.3.301.
4
Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain.鼠冠状病毒：JHM嗜神经毒株两种噬斑形态变异株的分离与鉴定
J Gen Virol. 1982 Dec;63(2):265-75. doi: 10.1099/0022-1317-63-2-265.
5
Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2).针对鼠冠状病毒JHM的杂交瘤抗体：纤突蛋白（E2）上抗原表位的特性分析
J Gen Virol. 1984 Nov;65 ( Pt 11):1931-42. doi: 10.1099/0022-1317-65-11-1931.
6
Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody.鼠肝炎病毒4型（JHM株）诱导的神经疾病在体内受到单克隆抗体的调节。
Virology. 1984 Jan 30;132(2):261-70. doi: 10.1016/0042-6822(84)90033-3.
7
Natural killer cell activity during mouse hepatitis virus infection: response in the absence of interferon.小鼠肝炎病毒感染期间的自然杀伤细胞活性：在无干扰素情况下的反应
Int J Cancer. 1983 Mar 15;31(3):309-14. doi: 10.1002/ijc.2910310310.
8
Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.JHM病毒脑脊髓炎中的脱髓鞘机制。电子显微镜研究。
Acta Neuropathol. 1973 Mar 30;24(1):76-85. doi: 10.1007/BF00691421.
9
Pathogenesis of demyelination induced by a mouse hepatitis.小鼠肝炎诱导的脱髓鞘发病机制。
Arch Neurol. 1973 May;28(5):298-303. doi: 10.1001/archneur.1973.00490230034003.
10
Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages.抗去唾液酸GM1血清与具有杀肿瘤作用和无杀肿瘤作用的小鼠巨噬细胞的反应性。
J Leukoc Biol. 1985 May;37(5):597-614. doi: 10.1002/jlb.37.5.597.
Zotero 插件