Jewett M A, Kong Y S, Goldberg S D, Sturgeon J F, Thomas G M, Alison R E, Gospodarowicz M K
Department of Surgery (Urology), Wellesley Hospital, Ontario Cancer Institute, Toronto, Canada.
J Urol. 1988 Jun;139(6):1220-4. doi: 10.1016/s0022-5347(17)42869-2.
The principal morbidity of retroperitoneal lymphadenectomy is the potential loss of ejaculation and, therefore, fertility owing to damage of the retroperitoneal sympathetic nerves that form the superior hypogastric plexus. We describe the results of our retroperitoneal lymphadenectomy when individual nerves from the sympathetic ganglia are identified and preserved while still performing a thorough bilateral retroperitoneal lymphadenectomy. The nerve-sparing procedure was technically feasible in 20 of 30 consecutive patients and it was only impractical with extensive gross disease. Of the 20 patients 18 (90 per cent) ejaculate, including 8 with bulky (5 cm. or more) residual retroperitoneal disease who underwent a successful nerve-sparing operation. All 12 patients (100 per cent) with nonbulky disease ejaculate. With short followup, no retroperitoneal recurrences have been detected. This technique is an alternative to limited dissection designed to spare nerves using boundaries based on the patterns of metastatic involvement.
腹膜后淋巴结清扫术的主要发病风险是射精功能丧失,进而因构成上腹下丛的腹膜后交感神经受损而导致生育能力丧失。我们描述了在进行彻底的双侧腹膜后淋巴结清扫术时,识别并保留来自交感神经节的单根神经的腹膜后淋巴结清扫术的结果。在连续30例患者中,有20例患者的保留神经手术在技术上是可行的,只有在存在广泛肉眼可见病变时才不可行。在这20例患者中,18例(90%)仍有射精功能,其中包括8例腹膜后残留病变体积较大(5厘米或更大)但成功接受了保留神经手术的患者。所有12例(100%)病变体积不大的患者均有射精功能。由于随访时间较短,尚未检测到腹膜后复发。该技术是一种替代有限解剖的方法,有限解剖旨在根据转移累及模式设定边界来保留神经。