帕金森病扫视任务期间瞳孔对认知负荷的反应。
Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease.
作者信息
Ranchet M, Orlosky J, Morgan J, Qadir S, Akinwuntan A E, Devos H
机构信息
Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; University of Lyon, F-69000 Lyon, France; French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR), TS2, LESCOT, F-69500 Bron, France.
Cybermedia Center, Toyonaka Educational Research Center 5F, Osaka University, 1-32 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
出版信息
Behav Brain Res. 2017 Jun 1;327:162-166. doi: 10.1016/j.bbr.2017.03.043. Epub 2017 Mar 31.
The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score≥26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score<26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.
帕金森病（PD）中认知负荷与认知障碍之间的关系目前尚不明确。本研究比较了PD患者与对照组在扫视任务期间的认知负荷。16名对照组、11名无明显认知障碍的PD患者（PD-NCI）（蒙特利尔认知评估量表[MOCA]评分≥26）和10名有认知障碍的PD患者（PD-CI）（MOCA评分<26）进行了同向扫视和反向扫视任务。比较了三组之间通过瞳孔记录提取的认知负荷及其他眼动指标。在同向扫视任务中，PD-NCI患者比对照组表现出更大的认知负荷。PD-CI患者在同向扫视任务中也比PD-NCI患者和对照组表现出更多的认知负荷。三组之间在其他眼动指标上未发现差异。认知负荷可用于区分PD患者的不同认知状态。PD-NCI患者认知负荷增加与认知衰退之间的因果关系应是未来研究的重点。
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