tau 和淀粉样β蛋白分别与衰老大脑的功能网络变化有关。
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain.
机构信息
Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
出版信息
Alzheimers Dement. 2017 Nov;13(11):1261-1269. doi: 10.1016/j.jalz.2017.02.011. Epub 2017 Mar 30.
INTRODUCTION
Misfolded tau and amyloid β (Aβ) proteins progressively accumulate in the human brain, causing altered neuronal function and neurodegeneration. This study sought to investigate whether the wide spectrum of functional reorganization in aging brains of cognitively normal individuals relates to specific pathological patterns of tau and Aβ deposits.
METHODS
We used functional connectivity neuroimaging and in vivo tau and Aβ positron emission tomography scans to study cortical spatial relationships between imaging modalities.
RESULTS
We found that a negative association between tau and functional connectivity combined with a positive association between Aβ and functional connectivity is the most frequent cortical pattern among elderly subjects. Moreover, we found specific brain areas that interrelate hypoconnectivity and hyperconnectivity regions.
DISCUSSION
Our findings have critical implications to understanding how the two main elements of Alzheimer's disease-related pathology affect the aging brain and how they cause alterations in large-scale neuronal circuits.
简介
错误折叠的 tau 蛋白和淀粉样蛋白 β（Aβ）蛋白在人类大脑中逐渐积累，导致神经元功能改变和神经退行性变。本研究旨在探讨认知正常个体衰老大脑中广泛的功能重组是否与 tau 和 Aβ 沉积的特定病理模式有关。
方法
我们使用功能连接神经影像学和体内 tau 和 Aβ 正电子发射断层扫描来研究成像模式之间的皮质空间关系。
结果
我们发现 tau 与功能连接之间的负相关，以及 Aβ 与功能连接之间的正相关，是老年受试者中最常见的皮质模式。此外，我们发现了特定的大脑区域，它们相互关联着连接不足和连接过度的区域。
讨论
我们的发现对于理解阿尔茨海默病相关病理学的两个主要因素如何影响衰老大脑以及它们如何导致大规模神经元回路的改变具有重要意义。
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