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感染患者的临床特征及预后因素。

Clinical characteristics and prognostic factors of patients with infections.

作者信息

Batra Priyam, Mathur Purva, Misra Mahesh C

机构信息

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Lab Physicians. 2017 Apr-Jun;9(2):132-135. doi: 10.4103/0974-2727.199639.

Abstract

INTRODUCTION

earlier had limited pathogenic potential, but now with growing degree of immunosuppression in general population, it is being recognized as an important nosocomial pathogen.

METHODOLOGY

A retrospective 7 years study was carried out to determine the clinical characteristics of all patients with infections, antibiotic resistance pattern, and risk factors associated with hospital mortality. All patients with culture positivity were identified and their medical records were reviewed. Risk factor associated with hospital mortality was analyzed.

RESULTS

A total of 123 samples obtained from 88 patients were culture positive. Most patients presented with bacteremia (45, 51%) followed by pneumonia (37, 42%) and skin and soft tissue infections (6, 7%). About 23 of 88 infected patients had co-infection. Percentage resistance to cotrimoxazole; 8 (5.4%) was lower than that for levofloxacin; 18 (12%). Twenty-eight patients died during hospital stay. Intensive Care Unit admission ( = 0.0002), mechanical ventilation ( = 0.0004), central venous catheterization ( = 0.0227), urethral catheterization ( = 0.0484), and previous antibiotic intake ( = 0.0026) were independent risk factors associated with mortality.

CONCLUSION

Our findings suggest that can cause various infections irrespective of patient's immune status and irrespective of potential source. Thus, should be thought of as potential pathogen and its isolation should be looked with clinical suspicion.

摘要

引言

早期其致病潜力有限,但如今随着普通人群免疫抑制程度的增加,它正被视为一种重要的医院病原体。

方法

进行了一项为期7年的回顾性研究,以确定所有感染患者的临床特征、抗生素耐药模式以及与医院死亡率相关的危险因素。确定所有培养阳性的患者,并查阅他们的病历。分析与医院死亡率相关的危险因素。

结果

共从88例患者中获取了123份培养阳性样本。大多数患者表现为菌血症(45例,51%),其次是肺炎(37例,42%)和皮肤及软组织感染(6例,7%)。88例感染患者中约有23例合并感染。对复方新诺明的耐药率为8例(5.4%),低于左氧氟沙星的18例(12%)。28例患者在住院期间死亡。入住重症监护病房(P = 0.0002)、机械通气(P = 0.0004)、中心静脉置管(P = 0.0227)、尿道插管(P = 0.0484)以及先前使用抗生素(P = 0.0026)是与死亡率相关的独立危险因素。

结论

我们的研究结果表明,无论患者的免疫状态如何以及潜在来源如何,均可引起各种感染。因此,应将视为潜在病原体,对其分离应结合临床怀疑进行观察。

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