监督下的结构化有氧运动训练计划对II型糖尿病患者高密度和低密度脂蛋白的影响。
Effects of supervised structured aerobic exercise training program on high and low density lipoprotein in patients with type II diabetes mellitus.
作者信息
Shakil-Ur-Rehman Syed, Karimi Hossein, Gillani Syed Amir
机构信息
Syed Shakil-ur-Rehman, Principal/Associate Professor, Riphah College of Rehabilitation Sciences, Riphah International University, Islamabad, Pakistan. PhD Physical Therapy Student, University Institute of Physical Therapy, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
Hossein Karimi, Professor, University Institute of Physical Therapy, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
出版信息
Pak J Med Sci. 2017 Jan-Feb;33(1):96-99. doi: 10.12669/pjms.331.11758.
BACKGROUND AND OBJECTIVE
Hyperlipidemia and dyslipidemia are very common conditions among patients with Type-2 diabetes mellitus (T2DM) and associated with increased risk of coronary heart diseases. Physical activity and exercises along with medical management and dietary plan are common strategies to use for the management of deranged lipid profile in patients with T2DM. We aimed to determine the effects of supervised structured aerobic exercise training (SSAET) program on high and low density lipoprotein in patients with T2DM.
METHODS
This randomized control trial study was conducted at Riphah Rehabilitation Research Centre (RRRC), Pakistan Railway General Hospital (PRGH) Rawalpindi from 1 January 2015 to 30 March 2016. The inclusion criteria was Type-2 diabetes patients of both gender aged between 40 to 70 years. Patients with severe complications like coronary artery diseases (CAD), and other serious complications like diabetic foot, and severe knee and hip osteoarthritis (OA) were excluded from the study. A total of 195 patients diagnosed with T2DM were screened out and 102 were selected for the study as per the inclusion criteria. All participants were randomly assigned into two groups, experimental 'A' (n=51) and control 'B' (n=51). Patients in group A were treated with SSAET program of 25 weeks at 3 days a week in addition to routine medical management, while patients in Group-B were on their routine medications and dietary plan. Serum LDL, and HDL were tested at baseline and after 25 weeks. The data was analysed through SPSS 20.
RESULTS
Mean and standard deviation of LDL in group A (n=51) was 118.56±19.17 (pre) and 102.64±13.33 (post), while the mean and standard deviation for Group-B (n=51) was 116.50±18.45 (Pre) and 109.88±17.13 (post). Both groups showed improvement but, Group-A treated with SSAET along with RMM showed significantly higher (P Value ≤ 0.05) improvement as compared with group B treated with RMM alone. Mean and standard deviation of HDL in Group-A was 42.70±8.06 (pre) and 47.47±7.16 (post), while the mean and standard deviation of group B is 43.37±8.15 (Pre) and 44.41±7.91 (post). Both groups showed improvement but Group-A treated with SSAET program along with RMM showed significantly higher (P Value ≤ 0.05) improvement than group B treated with RMM alone.
CONCLUSION
SSAET program along with RMM is more effective strategy for the management of deranged lipid profile in patients with T2DM.
背景与目的
高脂血症和血脂异常在2型糖尿病（T2DM）患者中非常常见，且与冠心病风险增加相关。体育活动和锻炼，以及药物治疗和饮食计划是管理T2DM患者紊乱血脂谱的常用策略。我们旨在确定有监督的结构化有氧运动训练（SSAET）计划对T2DM患者高密度和低密度脂蛋白的影响。
方法
这项随机对照试验研究于2015年1月1日至2016年3月30日在巴基斯坦拉瓦尔品第巴基斯坦铁路总医院（PRGH）的里法康复研究中心（RRRC）进行。纳入标准为年龄在40至70岁之间的男女2型糖尿病患者。患有严重并发症如冠状动脉疾病（CAD）以及其他严重并发症如糖尿病足、严重膝关节和髋关节骨关节炎（OA）的患者被排除在研究之外。总共筛选出195例诊断为T2DM的患者，根据纳入标准选择102例进行研究。所有参与者被随机分为两组，实验组“A”（n = 51）和对照组“B”（n = 51）。A组患者除常规药物治疗外，接受为期25周、每周3天的SSAET计划治疗，而B组患者继续其常规药物治疗和饮食计划。在基线和25周后检测血清低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。数据通过SPSS 20进行分析。
结果
A组（n = 51）LDL的均值和标准差在治疗前为118.56±19.17，治疗后为102.64±13.33，而B组（n = 51）的均值和标准差在治疗前为116.50±18.45，治疗后为109.88±17.13。两组均有改善，但接受SSAET联合常规药物治疗的A组与仅接受常规药物治疗的B组相比，改善更为显著（P值≤0.05）。A组HDL的均值和标准差在治疗前为42.70±8.06，治疗后为47.47±7.16，而B组的均值和标准差在治疗前为43.37±8.15，治疗后为44.41±7.91。两组均有改善，但接受SSAET计划联合常规药物治疗的A组比仅接受常规药物治疗的B组改善更为显著（P值≤0.05）。
结论
SSAET计划联合常规药物治疗是管理T2DM患者紊乱血脂谱更有效的策略。
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