Afrifa Justice, Essien-Baidoo Samuel, Baffour Gyau Albert, Ephraim Richard Kobina Dadzie
Department of Medical Laboratory Technology, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Obstet Gynecol Int. 2017;2017:6030943. doi: 10.1155/2017/6030943. Epub 2017 Mar 7.
Malaria is known to have devastating effects on mortality in tropical and subtropical regions with the effect being magnified in people with weakened immunity such as those in pregnancy. We assessed the effect of malaria on renal function of pregnant women receiving antenatal care in a mesoendemic area of Ghana. A case-control study that enrolled a total of 100 pregnant women (50 with confirmed gestational malaria as cases and 50 without malaria as controls). Sociodemographic characteristics, obstetric history (obtained with a questionnaire), urea, creatinine, sodium, and potassium were analyzed using a chemistry automated analyzer. Plasma urea and creatinine were significantly increased ( = 0.0003 and < 0.0001, resp.) among cases compared to the controls. Also the levels of urea ( = 0.033), creatinine ( = 0.032), and parasitaemia (0.016) were significantly increased with increasing gestational age. Malaria has a significant impact on renal function (most importantly, urea and creatinine) and is also significantly associated with increasing gestational age among our study participants.
众所周知，疟疾对热带和亚热带地区的死亡率具有毁灭性影响，而这种影响在免疫力较弱的人群（如孕妇）中会被放大。我们评估了疟疾对加纳一个中度流行地区接受产前护理的孕妇肾功能的影响。一项病例对照研究共纳入了100名孕妇（50名确诊为妊娠期疟疾的孕妇为病例组，50名未患疟疾的孕妇为对照组）。使用化学自动分析仪分析社会人口学特征、产科病史（通过问卷调查获得）、尿素、肌酐、钠和钾。与对照组相比，病例组的血浆尿素和肌酐显著升高（分别为=0.0003和<0.0001）。此外，随着孕周增加，尿素（=0.033）、肌酐（=0.032）和寄生虫血症（0.016）水平也显著升高。在我们的研究参与者中，疟疾对肾功能（最重要的是尿素和肌酐）有显著影响，并且也与孕周增加显著相关。
