来自恶性疟原虫的S抗原基因包含一个新的重复序列。

An S antigen gene from Plasmodium falciparum contains a novel repetitive sequence.

作者信息

Nicholls S C, Hillman Y, Lockyer M J, Odink K G, Holder A A

机构信息

Department of Molecular Biology, Wellcome Biotech, Beckenham, U.K.

出版信息

Mol Biochem Parasitol. 1988 Feb;28(1):11-9. doi: 10.1016/0166-6851(88)90174-0.

DOI:10.1016/0166-6851(88)90174-0

PMID:2836730

Abstract

The complete sequence of the gene coding for the S antigen from the Wellcome (West African) strain of Plasmodium falciparum has been obtained. It contains a central repetitive region consisting of 65 copies of a partially degenerate 24 bp sequence, coding for a conserved 8 amino acid repeat (Gly Pro Asn Ser Asp Gly Asp Lys). The repeat sequence is different from those of S antigens characterised in other strains and thus represents a new S antigen serotype.

摘要

已获得恶性疟原虫威康（西非）株编码S抗原的基因的完整序列。它包含一个中央重复区域，由65个部分退化的24 bp序列拷贝组成，编码一个保守的8氨基酸重复序列（甘氨酸脯氨酸天冬酰胺丝氨酸天冬氨酸甘氨酸天冬氨酸赖氨酸）。该重复序列与其他株中鉴定的S抗原的重复序列不同，因此代表一种新的S抗原血清型。