Trunin Yury, Golanov Andrey V, Kostjuchenko Valery V, Galkin Mikhail, Konovalov Alexander N
Radiology and Radiosurgery, Burdenko Neurosurgery Institute.
Department of Radiation Oncology, Burdenko Neurosurgery Institute.
Cureus. 2017 Feb 21;9(2):e1045. doi: 10.7759/cureus.1045.
Pilocytic astrocytomas are the most common gliomas (World Health Organization (WHO) grade 1) in children. According to many authors, stereotactic irradiation (radiotherapy and radiosurgery) is an effective method that provides a prolonged, recurrence-free survival in patients who have had partial tumor removal or in patients with an unresectable tumor. We present a case of a patient with midbrain pilocytic astrocytoma that enlarged considerably in the first six months after irradiation and then diminished in size during the next six months without any antitumor treatment. The clinical and radiological follow-up data for this patient, the surgery results for similar patients, and the data from other authors led us to the conclusion that early tumor volume enlargement after irradiation is usually pseudoprogression.
毛细胞型星形细胞瘤是儿童中最常见的胶质瘤（世界卫生组织（WHO）1级）。许多作者认为，立体定向放射治疗（放疗和放射外科）是一种有效的方法，可使部分肿瘤切除患者或无法切除肿瘤的患者获得长期无复发生存。我们报告一例中脑毛细胞型星形细胞瘤患者，其肿瘤在放疗后的前六个月显著增大，随后在接下来的六个月内未接受任何抗肿瘤治疗的情况下体积缩小。该患者的临床和影像学随访数据、类似患者的手术结果以及其他作者的数据使我们得出结论，放疗后早期肿瘤体积增大通常是假性进展。
