一种自旋标记柔红霉素类似物的药代动力学
Pharmacokinetics of a spin-labeled rubomycin analog.
作者信息
Konovalova N P, Diatchkovskaya R F, Kukushkina G V, Volkova L M, Varfolomeev V N, Dombrovsky L S, Shapiro A B
机构信息
Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
出版信息
Neoplasma. 1988;35(2):185-90.
PMID:2836742
Abstract
Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established.
摘要
对柔红霉素的自旋标记类似物（ruboxyl）的药代动力学进行了研究。发现正常动物和荷瘤动物的ruboxyl药代动力学存在差异。大部分药物在6小时内排出。确定了ruboxyl和硝酰自由基药代动力学的差异。
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