MacKenzie J M, Franks A J, van Hille P T, Cameron M M
Department of Pathology, University of Leeds, UK.
Neuropathol Appl Neurobiol. 1988 Jan-Feb;14(1):71-9. doi: 10.1111/j.1365-2990.1988.tb00867.x.
Oligodendrogliomas may comprise a biologically heterogenous group of tumours. There is disagreement about the relationship between their histological features and subsequent behaviour, and evolution of histologically typical oligodendrogliomas into more malignant neoplasms has been described. We describe a supratentorial oligodendroglioma in a 4-year-old boy which recurred 9 months after initial resection when it showed foci of histologically primitive cells, not present in the initial specimen. It recurred again at the same site 20 months later following a course of radiotherapy, but showed on this occasion the appearances of a primitive neuroectodermal tumour (PNET) with astrocytic and ependymal, but not oligodendroglial, differentiation. The evidence suggests evolution of an oligodendroglioma into a PNET, and raises the possibility that some oligodendrogliomas may arise by differentiation from a pool of proliferating primitive cells which may occasionally become the dominant population.
少突胶质细胞瘤可能是一组生物学上异质性的肿瘤。关于其组织学特征与后续行为之间的关系存在分歧，并且已经描述了组织学典型的少突胶质细胞瘤演变为更恶性肿瘤的情况。我们描述了一名4岁男孩的幕上少突胶质细胞瘤，该肿瘤在初次切除9个月后复发，此时显示出初始标本中不存在的组织学原始细胞灶。在接受一个疗程的放疗后20个月，它在同一部位再次复发，但这次表现为原始神经外胚层肿瘤（PNET），具有星形胶质细胞和室管膜细胞分化，但无少突胶质细胞分化。证据表明少突胶质细胞瘤演变成了PNET，并提出了一些少突胶质细胞瘤可能由一群增殖的原始细胞分化而来的可能性，这些原始细胞偶尔可能成为优势群体。
