Alonso Flavio H, Phan Aria, O'Connell Kelly, Vasilatis Demitria M
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
J Vet Diagn Invest. 2025 Apr 16:10406387251331553. doi: 10.1177/10406387251331553.
A 10-y-old castrated male German Wirehaired Pointer dog was presented for referral evaluation of a brain mass and craniotomy. Pertinent history included acute onset of cluster seizures; the systemic physical examination was largely unremarkable. Thorough laboratory and imaging screening ruled out extracranial causes for the presenting clinical signs. MRI revealed a hemorrhagic and strongly contrast-enhancing mass in the left frontal lobe. Upon craniotomy, the lesion was abnormal cortical parenchyma with surrounding malacic tissue, which was excised and submitted for microscopic analyses. Cytologic examination of a squash preparation of the mass revealed a mildly inflamed and hemorrhagic neoplasm, with oligodendroglioma or an embryonal CNS neoplasm as primary differential diagnoses. Histopathology with immunohistochemistry confirmed a high-grade oligodendroglioma with embryonal morphology.
一只10岁去势雄性德国刚毛指示犬因脑肿瘤和开颅手术转诊评估前来就诊。相关病史包括簇状癫痫急性发作；全身体格检查基本无异常。全面的实验室和影像学筛查排除了导致当前临床症状的颅外病因。磁共振成像（MRI）显示左额叶有一个出血性且强化明显的肿块。开颅手术时，病变为异常的皮质实质，周围有软化组织，将其切除并送去做显微镜分析。对肿块涂片标本进行细胞学检查发现是一个轻度炎症性和出血性肿瘤，初步鉴别诊断为少突胶质细胞瘤或胚胎性中枢神经系统肿瘤。免疫组化的组织病理学检查证实为具有胚胎形态的高级别少突胶质细胞瘤。
