Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines) Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan.
Phytomedicine. 1996 Sep;3(2):203-9. doi: 10.1016/S0944-7113(96)80037-7.
Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 β (IL-1 β) generation from human leukocytes. The free radical scavenging activity together with IL-1 β and nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.
蜂胶是蜜蜂从植物材料中制备的一种胶，用于将蜂巢粘在蜂巢壁上。蜂胶在日本作为一种健康饮品而广受欢迎，人们相信蜂胶可以治疗炎症、心脏病，甚至糖尿病和癌症。我们评估了蜂胶对链脲佐菌素（STZ）诱导的大鼠胰岛β细胞毒性的保护作用。蜂胶的水提取物（PWE）可完全防止 STZ 对胰岛β细胞的破坏。PWE 的保护作用几乎与烟酰胺相当。PWE 还抑制了人白细胞介素-1β（IL-1β）的产生。自由基清除活性以及 IL-1β 和一氧化氮（NO）合酶抑制活性被认为是 PWE 对抗 STZ 毒性的保护作用的主要因素。
