Liao Fan, Shi Renyi, Sha Yuchen, Xia Jianhui, Liao Weilin, Lei Aiwen
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. China.
Chem Commun (Camb). 2017 Apr 13;53(31):4354-4357. doi: 10.1039/c7cc01707c.
Pd/Cu catalyzed oxidative dual C-H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C-C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C-H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.
由于通过碳-碳键形成会产生副产物，钯/铜催化的氧化双C-H键活化/羰基化仍然是一个巨大的挑战。在此，我们开发了一种直接的钯/铜催化的氧化双C-H键羰基化过程，以从容易获得的N-芳基吡咯和一氧化碳制备具有生物学和药学重要性的氟氮杂环戊二烯。在该转化过程中，多种官能团具有良好的耐受性，并且氧气可作为唯一的终端氧化剂来促进氧化羰基化过程。
