Shi Renyi, Niu Huiying, Lu Lijun, Lei Aiwen
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, P. R. China.
Chem Commun (Camb). 2017 Feb 2;53(11):1908-1911. doi: 10.1039/c6cc08701a.
It is important to achieve diverse functionalization of tertiary anilines due to their importance in biological molecules, pharmaceutical, functional materials, and ligands. A straightforward Pd/Cu-catalyzed oxidative C-H bond activation/N-dealkylative carbonylation of tertiary [1,1'-biphenyl]-2-anilines towards the synthesis of various biologically important phenanthridin-6(5H)-ones has been developed. A wide range of functional groups are well tolerated in this transformation. Moreover, O is utilized as the terminal oxidant to promote the oxidative carbonylation process.
由于叔苯胺在生物分子、药物、功能材料和配体中具有重要性，实现其多样化官能团化非常重要。已开发出一种直接的钯/铜催化的叔[1,1'-联苯]-2-苯胺的氧化C-H键活化/N-脱烷基羰基化反应，用于合成各种具有重要生物学意义的菲啶-6(5H)-酮。在该转化过程中，多种官能团具有良好的耐受性。此外，氧气被用作终端氧化剂来促进氧化羰基化过程。
