比较三种不同年份多发性硬化症的疾病经济负担：一项基于人群的研究。
Comparing costs of illness of multiple sclerosis in three different years: A population-based study.
机构信息
Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Centre for Person-Centred Care (GPCC) and Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Analysis and Forecast, Swedish Social Insurance Agency, Stockholm, Sweden.
出版信息
Mult Scler. 2018 Apr;24(4):520-528. doi: 10.1177/1352458517702549. Epub 2017 Apr 3.
BACKGROUND
Little is known about changes in the costs of illness (COI) among multiple sclerosis (MS) patients during recent years.
OBJECTIVES
To compare the COI among MS patients and matched controls in 2006, 2009, and 2012, respectively, indicating the costs attributable to the MS disease.
METHODS
Three cross-sectional datasets were analyzed, including all MS patients in Sweden aged 20-60 years and five matched controls for each of them. The analyses were based on 10,531 MS patients and 52,655 matched controls for 2006, 11,722 and 58,610 individuals for 2009, and 12,789 and 63,945 for 2012. Nationwide registers, including prescription drug use, specialized healthcare, sick leave, and disability pension, were linked to estimate the prevalence-based COI.
RESULTS
Adjusted for inflation, the average difference in COI between MS patients and matched controls were Swedish Krona (SEK) 243,751 (95% confidence interval: SEK 239,171-248,331) in 2006, SEK 238,971 (SEK 234,516-243,426) in 2009, and SEK 225,923 (SEK 221,630-230,218) in 2012. The difference in indirect costs were SEK 170,502 (SEK 166,478-174,525) in 2006, SEK 158,839 (SEK 154,953-162,726) in 2009, and SEK 141,280 (SEK 137,601-144,960) in 2012.
CONCLUSION
The inflation-adjusted COI of MS patients was lower in 2012 than in 2006, in particular regarding indirect costs.
背景
对于多发性硬化症（MS）患者近年来疾病经济负担（COI）的变化知之甚少。
目的
分别比较 2006 年、2009 年和 2012 年 MS 患者与匹配对照者的 COI，指出归因于 MS 疾病的成本。
方法
分析了 3 个横断面数据集，包括瑞典所有年龄在 20-60 岁的 MS 患者和每位患者的 5 个匹配对照者。分析基于 2006 年的 10531 名 MS 患者和 52655 名匹配对照者、2009 年的 11722 名和 58610 名以及 2012 年的 12789 名和 63945 名。使用全国性登记处（包括处方药使用、专科医疗、病假和残疾抚恤金）来估算基于患病率的 COI。
结果
经通胀调整后，2006 年 MS 患者与匹配对照者 COI 的平均差异为 243751 瑞典克朗（95%置信区间：239171-248331 瑞典克朗），2009 年为 238971 瑞典克朗（234516-243426 瑞典克朗），2012 年为 225923 瑞典克朗（221630-230218 瑞典克朗）。间接成本的差异在 2006 年为 170502 瑞典克朗（166478-174525 瑞典克朗），2009 年为 158839 瑞典克朗（154953-162726 瑞典克朗），2012 年为 141280 瑞典克朗（137601-144960 瑞典克朗）。
结论
经通胀调整后，2012 年 MS 患者的 COI 低于 2006 年，尤其是间接成本。
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