Kim Albert, Lang Thomas, Xue Meilang, Wijewardana Aruna, Jackson Chris, Vandervord John
Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia.
Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia.
Int J Mol Sci. 2017 Apr 3;18(4):758. doi: 10.3390/ijms18040758.
Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of γδ T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response.
烧伤是一个全球性的公共卫生问题，估计每年导致26.5万人死亡。炎症对于提供生长因子、细胞因子和趋化因子至关重要，这些因子可将T细胞和髓样细胞募集到烧伤伤口部位以促进伤口愈合。然而，大面积烧伤会通过广泛释放大量促炎介质引发显著的病理生理炎症反应，使患者易患全身炎症反应综合征、脓毒症和多器官功能衰竭。最近，关于γδ T细胞和Th-17细胞在这种炎症反应的调节和传播中的作用，已有很有前景的研究。本研究综述了目前关于烧伤后免疫反应的文献。
