Powell N, MacDonald T T
Division of Transplantation Immunology and Mucosal Biology, Department of Experimental Immunobiology, Kings College London, London, UK.
Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Parasite Immunol. 2017 Jun;39(6). doi: 10.1111/pim.12430.
In recent years, there have been significant advances in our understanding of the mucosal immune system. In addition to unravelling some of the complexities of this system, including the discovery of completely new cells types, further insights into the three-way interactions between mucosal immune cells, the intestinal epithelium and the microbial communities colonizing the GI tract promise to redefine our understanding of how intestinal homeostasis is maintained, but also how dysregulation of these highly integrated interactions conspires to cause disease. In this review, we will discuss major recent advances in the role of key immune players in the gut, including innate lymphoid cells (ILCs), mucosa-associated invariant T cells (MAIT cells) and cells of the mononuclear phagocyte system (MPS), including how these cells interact with the intestinal epithelial and their crosstalk with components of the intestinal microbiota, and how these interactions shape host health.
近年来，我们对黏膜免疫系统的理解取得了重大进展。除了揭示该系统的一些复杂性，包括发现全新的细胞类型外，对黏膜免疫细胞、肠上皮细胞和定植于胃肠道的微生物群落之间的三方相互作用的进一步深入了解，有望重新定义我们对肠道稳态如何维持的认识，以及这些高度整合的相互作用的失调如何共同导致疾病的认识。在这篇综述中，我们将讨论肠道中关键免疫细胞（包括固有淋巴细胞（ILC）、黏膜相关恒定T细胞（MAIT细胞）和单核吞噬细胞系统（MPS）的细胞）作用的近期主要进展，包括这些细胞如何与肠上皮细胞相互作用以及它们与肠道微生物群成分的相互影响，以及这些相互作用如何影响宿主健康。
