Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; Department of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; Department of Pharmacy, North Sichuan Medical College, Nanchong 637000, China.
Life Sci. 2024 May 15;345:122612. doi: 10.1016/j.lfs.2024.122612. Epub 2024 Apr 6.
Gut microbiota is a complex microbial community with the ability of maintaining intestinal health. Intestinal homeostasis largely depends on the mucosal immune system to defense external pathogens and promote tissue repair. In recent years, growing evidence revealed the importance of gut microbiota in shaping intestinal mucosal immunity. Therefore, according to the existing findings, this review first provided an overview of intestinal mucosal immune system before summarizing the regulatory roles of gut microbiota in intestinal innate and adaptive immunity. Specifically, this review delved into the gut microbial interactions with the cells such as intestinal epithelial cells (IECs), macrophages, dendritic cells (DCs), neutrophils, and innate lymphoid cells (ILCs) in innate immunity, and T and B lymphocytes in adaptive immunity. Furthermore, this review discussed the main effects of gut microbiota dysbiosis in intestinal diseases and offered future research prospects. The review highlighted the key regulatory roles of gut microbiota in intestinal mucosal immunity via various host-microbe interactions, providing valuable references for the development of microbial therapy in intestinal diseases.
肠道微生物群是一个具有维持肠道健康能力的复杂微生物群落。肠道内环境的稳定在很大程度上依赖于黏膜免疫系统来抵御外来病原体并促进组织修复。近年来，越来越多的证据表明肠道微生物群在塑造肠道黏膜免疫方面的重要性。因此，根据现有研究结果，本综述首先概述了肠道黏膜免疫系统，然后总结了肠道微生物群在肠道固有和适应性免疫中的调节作用。具体而言，本综述深入探讨了肠道微生物与肠道上皮细胞（IECs）、巨噬细胞、树突状细胞（DCs）、中性粒细胞和固有淋巴细胞（ILCs）等细胞在固有免疫中的相互作用，以及 T 和 B 淋巴细胞在适应性免疫中的相互作用。此外，本综述还讨论了肠道微生物失调在肠道疾病中的主要影响，并提供了未来的研究展望。该综述通过各种宿主-微生物相互作用强调了肠道微生物群在肠道黏膜免疫中的关键调节作用，为肠道疾病的微生物治疗提供了有价值的参考。
