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本文引用的文献

1
Budesonide Oral Suspension Improves Symptomatic, Endoscopic, and Histologic Parameters Compared With Placebo in Patients With Eosinophilic Esophagitis.布地奈德混悬液治疗嗜酸性粒细胞性食管炎:与安慰剂相比,可改善症状、内镜和组织学参数。
Gastroenterology. 2017 Mar;152(4):776-786.e5. doi: 10.1053/j.gastro.2016.11.021. Epub 2016 Nov 23.
2
Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis.血清骨膜蛋白作为嗜酸性食管炎诊断和监测生物标志物的前瞻性评估。
Aliment Pharmacol Ther. 2016 Jul;44(2):189-97. doi: 10.1111/apt.13672. Epub 2016 May 18.
3
Evaluation of Histologic Cutpoints for Treatment Response in Eosinophilic Esophagitis.嗜酸性食管炎治疗反应的组织学切点评估
J Gastroenterol Hepatol Res. 2015 Oct 1;4(10):1780-1787. doi: 10.17554/j.issn.2224-3992.2015.04.562. Epub 2015 Oct 21.
4
Eosinophilic Esophagitis: An Evidence-Based Approach to Therapy.嗜酸性粒细胞性食管炎:基于证据的治疗方法。
J Investig Allergol Clin Immunol. 2016;26(1):8-18; quiz 2p following 18.
5
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.新开发并经验证的嗜酸性食管炎组织学评分系统及其在疾病诊断和监测方面优于嗜酸性粒细胞峰值计数的证据。
Dis Esophagus. 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470.
6
Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.症状在检测嗜酸性食管炎成人患者的内镜和组织学缓解方面准确性有限。
Gastroenterology. 2016 Mar;150(3):581-590.e4. doi: 10.1053/j.gastro.2015.11.004. Epub 2015 Nov 14.
7
Accuracy of the Eosinophilic Esophagitis Endoscopic Reference Score in Diagnosis and Determining Response to Treatment.嗜酸性食管炎内镜参考评分在诊断及判定治疗反应中的准确性
Clin Gastroenterol Hepatol. 2016 Jan;14(1):31-9. doi: 10.1016/j.cgh.2015.08.040. Epub 2015 Sep 25.
8
Peripheral blood eosinophils and other non-invasive biomarkers can monitor treatment response in eosinophilic oesophagitis.外周血嗜酸性粒细胞和其他非侵入性生物标志物可用于监测嗜酸性食管炎的治疗反应。
Aliment Pharmacol Ther. 2015 Nov;42(9):1122-30. doi: 10.1111/apt.13386. Epub 2015 Aug 27.
9
A Clinical Prediction Tool Identifies Cases of Eosinophilic Esophagitis Without Endoscopic Biopsy: A Prospective Study.一种临床预测工具可在无内镜活检的情况下识别嗜酸性食管炎病例:一项前瞻性研究。
Am J Gastroenterol. 2015 Sep;110(9):1347-54. doi: 10.1038/ajg.2015.239. Epub 2015 Aug 25.
10
Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity.嗜酸性粒细胞性食管炎:生活质量与临床、内镜及组织学活性的关系。
Aliment Pharmacol Ther. 2015 Oct;42(8):1000-10. doi: 10.1111/apt.13370. Epub 2015 Aug 14.

视觉模拟评分法和李克特量表是评估嗜酸性食管炎吞咽困难的简单且灵敏的工具。

A visual analogue scale and a Likert scale are simple and responsive tools for assessing dysphagia in eosinophilic oesophagitis.

作者信息

Reed C C, Wolf W A, Cotton C C, Dellon E S

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

出版信息

Aliment Pharmacol Ther. 2017 Jun;45(11):1443-1448. doi: 10.1111/apt.14061. Epub 2017 Mar 31.

DOI:10.1111/apt.14061
PMID:28370355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5419874/
Abstract

BACKGROUND

While symptom scores have been developed to evaluate dysphagia in eosinophilic oesophagitis (EoE), their complexity may limit clinical use.

AIM

To evaluate a visual analogue scale (VAS) and a 10-point Likert scale (LS) for assessment of dysphagia severity before and after EoE treatment.

METHODS

We conducted a prospective cohort study enrolling consecutive adults undergoing out-patient endoscopy. Incident cases of EoE were diagnosed per consensus guidelines. At diagnosis and after 8 weeks of treatment, symptoms were measured using the VAS, LS and the Mayo Dysphagia Questionnaire (MDQ). The percentage change in scores before and after treatment were compared overall, in treatment responders (<15 eos/hpf) and non-responders, and in patients without baseline dilation.

RESULTS

In 51 EoE cases, the median VAS decreased from 3.6 at baseline to 1.4 post-treatment (71% decrease), the LS decreased from 6 to 2 (67%) and the MDQ decreased from 20 to 10 (49%). The VAS correlated with both the LS (R = 0.77; P < 0.0001) and MDQ (R = 0.46, P = 0.001). After stratification by histological response, the LS decreased 70% in responders vs. 13% in non-responders (P = 0.02). In patients who did not receive baseline dilation, both the VAS and LS decreased significantly more in the histological responders.

CONCLUSIONS

Both the VAS and LS were responsive to successful treatment as measured by histologic improvement. Because the VAS and LS are simple to administer and are responsive to treatment, they can provide an efficient and objective method for assessing dysphagia severity in EoE in clinical practice.

摘要

背景

虽然已开发出症状评分来评估嗜酸性粒细胞性食管炎(EoE)中的吞咽困难,但评分的复杂性可能会限制其临床应用。

目的

评估视觉模拟量表(VAS)和10分制李克特量表(LS)在EoE治疗前后对吞咽困难严重程度的评估情况。

方法

我们进行了一项前瞻性队列研究,纳入连续接受门诊内镜检查的成年人。根据共识指南诊断EoE的新发病例。在诊断时和治疗8周后,使用VAS、LS和梅奥吞咽困难问卷(MDQ)测量症状。比较治疗前后评分的总体变化百分比,以及治疗有反应者(嗜酸性粒细胞<15个/高倍视野)、无反应者和未进行基线扩张患者的评分变化百分比。

结果

在51例EoE病例中,VAS中位数从基线时的3.6降至治疗后的1.4(下降71%),LS从6降至2(下降67%),MDQ从20降至10(下降49%)。VAS与LS(R = 0.77;P < 0.0001)和MDQ(R = 0.46,P = 0.001)均相关。按组织学反应分层后,有反应者的LS下降70%,无反应者下降13%(P = 0.02)。在未接受基线扩张的患者中,组织学有反应者的VAS和LS下降幅度均明显更大。

结论

通过组织学改善衡量,VAS和LS对成功治疗均有反应。由于VAS和LS易于实施且对治疗有反应,它们可为临床实践中评估EoE吞咽困难严重程度提供一种有效且客观的方法。