Loçasso Felipe Altino, Filho Hélcio Alvarenga, Alvarenga Regina Maria Papais, Schimidt Sérgio Luís, Fiorelli Filipe Kleinman, Ramos Plínio Dos Santos, Leidersnaider Sônia Cristina Leal, Blum Kenneth, Lewandrowski Kai-Uwe, Cunha-Junior Edezio Ferreira, Fiorelli Rossano Kepler Alvim
Programa de Pós-Graduação em Neurologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-004, Brazil.
Faculdade de Ciências Médicas de Três Rios (SUPREMA), Rio de Janeiro 25804-250, Brazil.
J Pers Med. 2024 Aug 22;14(8):886. doi: 10.3390/jpm14080886.
Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome characterized by widespread pain and a variety of other symptoms, including fatigue, cognitive dysfunction, and sleep disturbances. Recent research has highlighted the potential role of pro-inflammatory cytokines and neurotransmitters in the pathophysiology of FM. This study aimed to investigate the relationship between serum levels of interleukin-6 (IL-6) and serotonin with the clinical parameters observed in patients with fibromyalgia. Additionally, it sought to analyze the similarities and differences among the different groups classified by symptom severity.
This cross-sectional study included 26 female patients aged 20-70 diagnosed with FM according to the American College of Rheumatology (ACR) 2016 criteria and 14 healthy controls (HCs). Serum levels of IL-6 and serotonin were measured using electrochemiluminescence and high-performance liquid chromatography (HPLC), respectively.
FM patients exhibited significantly higher pain scores (VAS), anxiety, and depression levels compared to HCs. FIQ-R scores were significantly elevated in FM patients, with stratification showing 3.8% mild, 65.4% moderate, 23.1% severe, and 7.7% very severe cases. While no significant difference in IL-6 levels was observed between the FM patients and HCs, a trend towards increased IL-6 levels in patients with higher FIQ-R scores was noted. Serum serotonin levels were significantly lower in the FM patients than in the HCs, with moderate patients having lower levels than those classified as severe and very severe.
The study underscores the potential role of IL-6 and serotonin in the pathophysiology of FM, suggesting that these biomarkers could be relevant in assessing the severity and impact of FM. Further research is needed to elucidate these relationships and their implications for developing personalized treatment strategies.
纤维肌痛（FM）是一种慢性肌肉骨骼疼痛综合征，其特征为广泛疼痛及多种其他症状，包括疲劳、认知功能障碍和睡眠障碍。近期研究强调了促炎细胞因子和神经递质在FM病理生理学中的潜在作用。本研究旨在探讨血清白细胞介素-6（IL-6）和血清素水平与纤维肌痛患者临床参数之间的关系。此外，还试图分析按症状严重程度分类的不同组之间的异同。
这项横断面研究纳入了26名年龄在20 - 70岁之间、根据美国风湿病学会（ACR）2016标准诊断为FM的女性患者以及14名健康对照者（HCs）。分别采用电化学发光法和高效液相色谱法（HPLC）测定血清IL-6和血清素水平。
与HCs相比，FM患者的疼痛评分（VAS）、焦虑和抑郁水平显著更高。FM患者的FIQ-R评分显著升高，分层显示轻度病例占3.8%，中度病例占65.4%，重度病例占23.1%，极重度病例占7.7%。虽然FM患者与HCs之间未观察到IL-6水平有显著差异，但注意到FIQ-R评分较高的患者有IL-6水平升高的趋势。FM患者的血清血清素水平显著低于HCs，中度患者的血清素水平低于重度和极重度患者。
该研究强调了IL-6和血清素在FM病理生理学中的潜在作用，表明这些生物标志物可能与评估FM的严重程度和影响相关。需要进一步研究以阐明这些关系及其对制定个性化治疗策略的意义。
