Kameya S, Noda A, Isobe E, Watanabe T
Third Department of Internal Medicine, Aichi Medical University, Japan.
Am J Gastroenterol. 1988 Jun;83(6):664-6.
The sign of Leser-Trélat, which refers to the sudden appearance and rapid increase in size and number of seborrheic keratosis associated with a visceral malignant tumor, is very uncommon. This case concerns a 54-yr-old woman presenting with Leser-Trélat's sign associated with advanced gastric cancer. Seborrheic keratosis faded after resection of the tumor, but returned when the cancer recurred. At that time, 24-h urinary excretion of epidermal growth factor determined by radioreceptor assay was slightly elevated. Epidermal growth factor may play a part in the development of Leser-Trélat's sign.
Leser-Trélat征是指与内脏恶性肿瘤相关的脂溢性角化病突然出现且大小和数量迅速增加，这种情况非常罕见。该病例为一名54岁女性，出现与晚期胃癌相关的Leser-Trélat征。肿瘤切除后脂溢性角化病消退，但癌症复发时又再次出现。那时，通过放射受体测定法测定的24小时尿表皮生长因子排泄量略有升高。表皮生长因子可能在Leser-Trélat征的发生中起作用。
