Gastroenterology Unit, Thammasat University Hospital, Pathumthani, Thailand.
Department of Medicine, Chulabhorn International College of Medicine (CICM), Thammasat University, Pathumthani, Thailand.
Cancer Rep (Hoboken). 2021 Feb;4(1):e1305. doi: 10.1002/cnr2.1305. Epub 2020 Oct 19.
Gastric cancer ranks as a leading cause of cancer deaths worldwide. Information of prognostic factors related to gastric cancer are limited.
This study aimed to gather clinical data and prevalence of prognostic factors related to gastric adenocarcinoma in Thailand.
This retrospective cohort study was conducted at Thammasat University Hospital, Thailand between January 2010 and July 2018. Gastric adenocarcinoma patients were enrolled and followed up for at least 5 years. Total of 210 gastric tumor patients were enrolled. One hundred patients were diagnosed with gastric adenocarcinomas (57 men and 43 women, mean age = 61.1 years). The leading presenting symptoms were weight loss (65%), followed by dyspepsia (54%) and UGI bleeding. Common clinical manifestations were thrombocytosis (26%), followed by syndrome of inappropriate antidiuretic hormone (SIADH; 15%). Eosinophilia was present in early cancer (25.0% vs 6.5%, P = .123), while SIADH and thrombocytosis were more common in advanced stages (16.3% vs 0%, P = .602, and 28.3% vs 0%, P = .108, respectively). SIADH was significantly related to reduced 1-year survival rate compared to normal serum sodium levels (21.4% vs 71.4%, OR 0.109, 95% CI 0.024-0.497, P = .004). Five-year survival rates were worse in patients with SIADH, but better in patients with eosinophilia compared to patients without these conditions (0% vs 27.8%, P = .058 and 20.0% vs 7.8%, P = .375, respectively).
Thrombocytosis and SIADH were common in gastric cancer. SIADH was significantly correlated with poor 1-year survival. These clinical manifestations might be useful for predicting gastric cancer prognosis.
胃癌是全球癌症死亡的主要原因之一。目前有关胃癌预后因素的信息有限。
本研究旨在收集泰国与胃腺癌相关的临床数据和预后因素。
本回顾性队列研究于 2010 年 1 月至 2018 年 7 月在泰国玛希隆大学医院进行。入组并随访至少 5 年的胃腺癌患者。共入组 210 例胃肿瘤患者。其中 100 例患者被诊断为胃腺癌（57 名男性和 43 名女性，平均年龄 61.1 岁）。主要表现症状为体重减轻（65%），其次为消化不良（54%）和上消化道出血。常见的临床表现为血小板增多症（26%），其次是抗利尿激素不适当分泌综合征（SIADH；15%）。嗜酸性粒细胞增多见于早期癌症（25.0%比 6.5%，P=.123），而 SIADH 和血小板增多症在晚期更常见（16.3%比 0%，P=.602 和 28.3%比 0%，P=.108）。与血清钠水平正常相比，SIADH 显著与降低 1 年生存率相关（21.4%比 71.4%，OR 0.109，95%CI 0.024-0.497，P=.004）。与没有这些情况的患者相比，患有 SIADH 的患者 5 年生存率更差，但患有嗜酸性粒细胞增多的患者 5 年生存率更好（0%比 27.8%，P=.058 和 20.0%比 7.8%，P=.375）。
血小板增多症和 SIADH 在胃癌中很常见。SIADH 与较差的 1 年生存率显著相关。这些临床表现可能有助于预测胃癌的预后。
