合成并研究了 StNPs/树胶纳米粒用于丹参酸 B 口服给药系统的性质。
Synthesis and study the properties of StNPs/gum nanoparticles for salvianolic acid B-oral delivery system.
机构信息
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, China.
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, China.
出版信息
Food Chem. 2017 Aug 15;229:111-119. doi: 10.1016/j.foodchem.2017.02.059. Epub 2017 Feb 16.
To fabricate stable sized and shaped controlled release delivery systems for salvianolic acid B (Sal B), different food gums were individually added to short-chain glucan solution to prepare starch nanoparticles (StNPs)/gum nanocomposites by self-assembly, and Sal B was embedded in situ. The results showed that size of StNPs was reduced to ca. 45nm with the addition of chitosan and rosin, which decreased by over 50% than that of StNPs without the gum. The StNPs/guar gum nanocomposites had the largest size (109.2nm) among samples of StNPs with gums. The StNPs with chitosan and gum arabic exhibited an obvious core-shell structure. The loading capacities of Sal B in StNPs, StNPs/chitosan, and StNPs/gum arabic nanocomposites were 5.2, 8.26 and 8.08%, respectively. The in vitro release of Sal B from StNPs/gum nanocomposites were sustained and prolonged for over 12h, indicating that StNPs/gum nanocomposites are good candidates to control Sal B release.
为了制备丹参酸 B（Sal B）稳定尺寸和形状的控制释放给药系统，将不同的食用胶单独添加到短链葡聚糖溶液中，通过自组装制备淀粉纳米颗粒（StNPs）/胶纳米复合材料，并将 Sal B 原位嵌入。结果表明，加入壳聚糖和松香后，StNPs 的粒径减小到约 45nm，比没有胶的 StNPs 减小了 50%以上。在含有胶的 StNPs 样品中，StNPs/瓜尔胶纳米复合材料的粒径最大（109.2nm）。StNPs 与壳聚糖和阿拉伯胶表现出明显的核壳结构。StNPs、StNPs/壳聚糖和 StNPs/阿拉伯胶纳米复合材料中 Sal B 的载药量分别为 5.2%、8.26%和 8.08%。StNPs/胶纳米复合材料中 Sal B 的体外释放持续且延长超过 12h，表明 StNPs/胶纳米复合材料是控制 Sal B 释放的良好候选材料。
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