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基于DNA和环糊精聚合物的纳米载体在药物递送系统中的研究进展。

Advance of DNA and CCPs-based nanocarriers in drug delivery systems.

作者信息

Wu Yu, Yao Xihui, Chen Yun, Li Yinping, Tian Weiqun

机构信息

Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

出版信息

Biomed Mater Eng. 2017;28(s1):S255-S261. doi: 10.3233/BME-171648.

Abstract

Development of smart and functional polymeric carriers, which enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects, becomes a new requirement in the field of drug delivery. In the recent few decades, a great many advancements of polymer synthetic methods have led to a new generation of bioactive polymers' applications as drug controlled release carriers. In this review, we focus on the use of bioactive polymers for drug delivery system, with a particular in the utility of DNA-based nanocarriers and cell-penetrating peptides (CCPs)-based nanocarriers to provide precision control for drug targeting or stimuli responsive systems.

摘要

智能且功能性聚合物载体的开发成为药物递送领域的一项新要求,这种载体能够实现生物活性物质的可控或定时释放,从而提供更好的给药模式并将副作用降至最低。在最近几十年里,聚合物合成方法的诸多进展催生了新一代生物活性聚合物作为药物控释载体的应用。在本综述中,我们重点关注生物活性聚合物在药物递送系统中的应用,特别是基于DNA的纳米载体和基于细胞穿透肽(CCPs)的纳米载体在药物靶向或刺激响应系统中实现精准控制的应用。

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