Tang Xiaoming, Huang Kai, Dai Jian, Wu Zhaoying, Cai Liang, Yang Lili, Wei Jie, Sun Hailang
Department of Orthopedics, Huai'an First People's Hospital, Nanjing medical university, Huai'an, 223001, Jiangsu Province, PR China.
Department of orthopedics, Shanghai Zhabei Central Hospital, Shanghai, 200070, PR China.
Sci Rep. 2017 Apr 3;7(1):568. doi: 10.1038/s41598-017-00571-4.
The surfaces of nano-calcium silicate (n-CS)/polyetheretherketone (PK) composites were treated with abrasive paper and sand-blasting, and the surfaces performances of the as-treated composites were studied. The results showed that the surface roughness, hydrophilicity and mineralization of the simulated body fluid (SBF) of the composites surfaces were significantly improved, and the properties of the composites treated by with sand-blasting were better than those treated with abrasive paper. Moreover, the treated composites significantly promoted osteoblasts responses, such as cell attachment, spreading, proliferation and alkaline phosphatase (ALP) activity, compared to un-treated composites, and the cellular responses to the composites treated with sand-blasting were better than those treated with abrasive paper. The results suggested that surface treatment with sand-blasting was an effective method to greatly improve the surface bioperformances of the n-CS/PK composite, and this treated composite with improved bioactivity and cytocompatibility might be a promising implant material for orthopedic applications.
采用砂纸打磨和喷砂处理纳米硅酸钙（n-CS）/聚醚醚酮（PK）复合材料表面，并对处理后的复合材料表面性能进行了研究。结果表明，复合材料表面的粗糙度、亲水性和模拟体液（SBF）矿化程度显著提高，喷砂处理的复合材料性能优于砂纸打磨处理的复合材料。此外，与未处理的复合材料相比，处理后的复合材料显著促进了成骨细胞反应，如细胞附着、铺展、增殖和碱性磷酸酶（ALP）活性，且细胞对喷砂处理复合材料的反应优于砂纸打磨处理的复合材料。结果表明，喷砂表面处理是大幅提高n-CS/PK复合材料表面生物性能的有效方法，这种具有改善生物活性和细胞相容性的处理复合材料可能是一种有前景的骨科植入材料。
