Najeeb Shariq, Khurshid Zohaib, Matinlinna Jukka Pekka, Siddiqui Fahad, Nassani Mohammad Zakaria, Baroudi Kusai
Restorative Dental Sciences, Al-Farabi Colleges, King Abdullah Road, P.O. Box 85184, Riyadh 11891, Saudi Arabia.
School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Int J Dent. 2015;2015:381759. doi: 10.1155/2015/381759. Epub 2015 Oct 1.
Purpose. The aim of this review is to summarize and evaluate the relevant literature regarding the different ways how polyetheretherketone (PEEK) can be modified to overcome its limited bioactivity, and thereby making it suitable as a dental implant material. Study Selection. An electronic literature search was conducted via the PubMed and Google Scholar databases using the keywords "PEEK dental implants," "nano," "osseointegration," "surface treatment," and "modification." A total of 16 in vivo and in vitro studies were found suitable to be included in this review. Results. There are many viable methods to increase the bioactivity of PEEK. Most methods focus on increasing the surface roughness, increasing the hydrophilicity and coating osseoconductive materials. Conclusion. There are many ways in which PEEK can be modified at a nanometer level to overcome its limited bioactivity. Melt-blending with bioactive nanoparticles can be used to produce bioactive nanocomposites, while spin-coating, gas plasma etching, electron beam, and plasma-ion immersion implantation can be used to modify the surface of PEEK implants in order to make them more bioactive. However, more animal studies are needed before these implants can be deemed suitable to be used as dental implants.
目的。本综述的目的是总结和评估有关聚醚醚酮（PEEK）可通过不同方式进行改性以克服其生物活性有限的问题，从而使其适合作为牙科植入材料的相关文献。研究选择。通过PubMed和谷歌学术数据库进行电子文献检索，使用关键词“PEEK牙科植入物”“纳米”“骨整合”“表面处理”和“改性”。共发现16项体内和体外研究适合纳入本综述。结果。有许多可行的方法来提高PEEK的生物活性。大多数方法集中在增加表面粗糙度、增加亲水性和涂覆骨传导材料。结论。有多种方法可在纳米水平上对PEEK进行改性以克服其生物活性有限的问题。与生物活性纳米颗粒熔融共混可用于制备生物活性纳米复合材料，而旋涂、气体等离子体蚀刻、电子束和等离子体离子浸没注入可用于改性PEEK植入物的表面，使其具有更高的生物活性。然而，在这些植入物被认为适合用作牙科植入物之前，还需要更多的动物研究。
