Van der Zee C E, Brakkee J H, Gispen W H
Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, The Netherlands.
Eur J Pharmacol. 1988 Mar 15;147(3):351-7. doi: 10.1016/0014-2999(88)90168-9.
The efficacy of melanocortins (alpha-MSH and an ACTH-(4-9) analog, Org.2766) in accelerating functional recovery from sciatic nerve damage following various types of subcutaneous and oral administration was assessed in the rat. Furthermore, the effectiveness of the local delivery of melanocortins to the site of injury was examined. An accelerated recovery was evident following subcutaneous constant delivery of Org.2766 from an osmotic mini-pump and from biodegradable polymere microspheres, and was as effective as repeated subcutaneous injections of alpha-MSH or Org.2766. Oral administration of Org.2766 was ineffective. Local application of Org.2766, achieved by wrapping a peptide-impregnated biodegradable gelatine foam matrix around the site of injury, facilitated recovery as well. The biodegradable microspheres and gelatine foam matrix may be of importance in eventual clinical use as effective vehicles for administration of melanocortins in the treatment of peripheral nerve damage.
在大鼠中评估了黑素皮质素（α-促黑素细胞激素和一种促肾上腺皮质激素-（4-9）类似物，Org.2766）在通过各种皮下和口服给药方式加速坐骨神经损伤后功能恢复方面的疗效。此外，还研究了将黑素皮质素局部递送至损伤部位的有效性。通过渗透微型泵和可生物降解聚合物微球持续皮下递送Org.2766后，恢复明显加速，其效果与重复皮下注射α-促黑素细胞激素或Org.2766相同。口服Org.2766无效。通过在损伤部位包裹浸渍有肽的可生物降解明胶泡沫基质实现的Org.2766局部应用也促进了恢复。可生物降解微球和明胶泡沫基质作为在治疗周围神经损伤中施用黑素皮质素的有效载体，在最终临床应用中可能具有重要意义。
