van der Hoop R G, Brakkee J H, Kapelle A, Samson M, de Koning P, Gispen W H
Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, University of Utrecht, The Netherlands.
J Neurosci Methods. 1988 Dec;26(2):111-6. doi: 10.1016/0165-0270(88)90159-8.
The major caudal nerves of the rat provide an excellent model for longitudinal evaluation of nerve repair following a crush lesion. The surgical procedure and the method for testing sensory recovery are described in detail. Using this technique a clear, positive effect of ORG.2766 (an ACTH (4-9) analog) on the regeneration of sensory nerves could be shown. Results support the suggestion that ORG.2766 enhances the initial sprouting response, rather than exerting an effect on the growth rate of newly developed sprouts.
大鼠的主要尾神经为挤压损伤后神经修复的纵向评估提供了一个极佳的模型。详细描述了手术步骤和感觉恢复测试方法。运用该技术，可显示ORG.2766（一种促肾上腺皮质激素（4-9）类似物）对感觉神经再生有明显的积极作用。结果支持以下观点：ORG.2766增强了初始发芽反应，而非对新长出的芽的生长速率产生影响。
