Lipton J M
Department of Physiology, University of Texas Southwestern Medical Center, Dallas.
Yale J Biol Med. 1990 Mar-Apr;63(2):173-82.
alpha-melanocyte stimulating hormone (alpha-MSH), a peptide that occurs within the brain, the circulation, and other body sites, is a potent antipyretic agent when given centrally or peripherally. The peptide likewise inhibits inflammation and aspects of the acute-phase response. The combined evidence suggests that alpha-MSH molecules act as natural modulators of host reactions by antagonizing the central and peripheral actions of cytokines.
α-黑素细胞刺激素（α-MSH）是一种存在于大脑、血液循环及身体其他部位的肽，无论经中枢给药还是外周给药，它都是一种有效的解热剂。该肽同样能抑制炎症和急性期反应的某些方面。综合证据表明，α-MSH分子通过拮抗细胞因子的中枢和外周作用，充当宿主反应的天然调节剂。
