Modulation of host defense by the neuropeptide alpha-MSH.
作者信息
Lipton J M
机构信息
Department of Physiology, University of Texas Southwestern Medical Center, Dallas.
出版信息
Yale J Biol Med. 1990 Mar-Apr;63(2):173-82.
Abstract
alpha-melanocyte stimulating hormone (alpha-MSH), a peptide that occurs within the brain, the circulation, and other body sites, is a potent antipyretic agent when given centrally or peripherally. The peptide likewise inhibits inflammation and aspects of the acute-phase response. The combined evidence suggests that alpha-MSH molecules act as natural modulators of host reactions by antagonizing the central and peripheral actions of cytokines.
摘要
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