Manole Emilia, Bastian Alexandra E, Butoianu Niculina, Goebel Hans H
a "Victor Babes" National Institute of Pathology , Bucharest , Romania.
b Research Center , Colentina Clinical Hospital , Bucharest , Romania.
J Immunoassay Immunochem. 2017;38(2):115-126. doi: 10.1080/15321819.2017.1298525.
Idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of rare muscular diseases, with no clearly known causes. IIM frequently have an incomplete response to treatment due to the difficulty in distinguishing between IIM forms, and due to neglect their non-inflammatory causes. Important data concerning non-immune mechanisms in IIM pathology have been recently accumulated. There is a correlation between inflammatory and non-inflammatory mechanisms, but their involvement in IIM pathogenesis is still unknown. Here we review some of the most important data regarding the non-immune IIM pathology, highlighting possible future therapeutic targets: endoplasmic reticulum stress, ATP metabolism, ROS generation, autophagy, and microRNAs disturbances.
特发性炎性肌病（IIM）是一组病因不明的罕见肌肉疾病。由于难以区分IIM的不同类型，且忽视了其非炎症性病因，IIM对治疗的反应常常不完全。最近积累了有关IIM病理学中非免疫机制的重要数据。炎症和非炎症机制之间存在关联，但其在IIM发病机制中的作用仍不清楚。在此，我们回顾一些关于IIM非免疫病理学的最重要数据，强调未来可能的治疗靶点：内质网应激、ATP代谢、活性氧生成、自噬和微小RNA紊乱。
