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狼疮性蛋白丢失性肠病合并蛋白C和蛋白S缺乏诱导的血栓形成:1例病例报告并文献复习

Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.

作者信息

Lertnawapan Ratchaya, Sakonlaya Dussadee

机构信息

Faculty of Medicine; Thammasat University.

出版信息

Acta Reumatol Port. 2017 Jul-Sep;42(3):265-268.

PMID:28375198
Abstract

A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with high dose steroid, azathioprine, mycophenolate mofetil and cyclophosphamide. Bowel resection was performed without improvement. Fortunately, the patient responded to another course of pulse methyl prednisolone and a second line medication after surgery.

.
摘要

一名亚洲女性系统性红斑狼疮伴发盘状红斑狼疮的病例报告;患者出现水肿、胸腔积液、腹水及严重低蛋白血症。她还因胃肠道丢失导致严重的蛋白C和蛋白S缺乏,进而引发广泛血栓形成。其疾病对高剂量类固醇、硫唑嘌呤、霉酚酸酯和环磷酰胺治疗无效。行肠切除术后病情无改善。幸运的是,患者在术后对另一疗程的静脉注射甲泼尼龙及二线药物治疗有反应。

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Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.狼疮性蛋白丢失性肠病合并蛋白C和蛋白S缺乏诱导的血栓形成:1例病例报告并文献复习
Acta Reumatol Port. 2017 Jul-Sep;42(3):265-268.
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