Horiuchi Masahiro, Oda Shiro, Uno Tadashi, Endo Junko, Handa Yoko, Fukuoka Yoshiyuki
1 Division of Human Environmental Science, Mt. Fuji Research Institute , Yamanashi, Japan .
2 Department of Health and Welfare, School of Life Long Sport, Hokusho University , Hokkaido, Japan .
High Alt Med Biol. 2017 Jun;18(2):171-178. doi: 10.1089/ham.2016.0162. Epub 2017 Apr 4.
Horiuchi, Masahiro, Shiro Oda, Tadashi Uno, Junko Endo, Yoko Handa, and Yoshiyuki Fukuoka. Effects of short-term acclimatization at the summit of Mt. Fuji (3776 m) on sleep efficacy, cardiovascular responses, and ventilatory responses. High Alt Med Biol. 18:171-178, 2017.-We investigated the effects of a short period of acclimatization, at 3776 m on Mt. Fuji, on sleep parameters and related physiological responses. Physiological responses were assessed in seven healthy lowlander men during both daytime and sleep while at sea level (SL), as well as for three consecutive nights at high altitude (HA; 3776 m, day 1 [D1], D2, D3, and morning only of D4). Blood pressure variables, heart rate (HR), pulmonary ventilation (V), and breathing frequency (Bf) progressively increased each day, with significant differences between SL and HA (p < 0.05, respectively). In contrast, end-tidal PCO (PCO) progressively decreased each day with statistical differences between SL and D3 at HA (p < 0.05). During sleep at HA, mean arterial pressure (MAP) was stable, whereas it decreased during sleep at SL. Sleep efficacy, which was assessed by actigraphy, was linearly impaired with statistical differences between SL and D3 (p < 0.05). These impairments in sleep efficacy at HA were associated with higher MAP and HR, as well as lower Bf and PCO during the daytime (pooled data, p < 0.05, respectively). These results suggest that hypoxia-induced cardiovascular and ventilatory responses may be crucial contributors to changes in sleep efficacy at HA.
堀内正博、小田史郎、宇野忠、远藤纯子、半田洋子和福冈义之。富士山（3776米）山顶短期适应对睡眠效率、心血管反应和通气反应的影响。《高海拔医学与生物学》。2017年第18卷：第171 - 178页。——我们研究了在富士山3776米处短期适应对睡眠参数及相关生理反应的影响。对7名健康的低地男性在海平面（SL）白天和睡眠期间以及在高海拔（HA；3776米，第1天[D1]、D2、D3以及仅D4上午）连续三个晚上的生理反应进行了评估。血压变量、心率（HR）、肺通气量（V）和呼吸频率（Bf）每天都逐渐增加，SL和HA之间存在显著差异（分别为p < 0.05）。相比之下，呼气末二氧化碳分压（PCO₂）每天逐渐降低，SL和HA的D3之间存在统计学差异（p < 0.05）。在HA睡眠期间，平均动脉压（MAP）稳定，而在SL睡眠期间则降低。通过活动记录仪评估的睡眠效率呈线性受损，SL和D3之间存在统计学差异（p < 0.05）。HA睡眠效率的这些损害与白天较高的MAP和HR以及较低的Bf和PCO₂有关（汇总数据，分别为p < 0.05）。这些结果表明，低氧诱导的心血管和通气反应可能是HA睡眠效率变化的关键因素。
