Arismendi-Morillo Gabriel, Castellano-Ramírez Alan, Seyfried Thomas N
a Biological Researches Institute, Faculty of Medicine , University of Zulia , Maracaibo , Venezuela.
b Department of Biology , Boston College , Chestnut Hill , MA , USA.
Ultrastruct Pathol. 2017 May-Jun;41(3):234-244. doi: 10.1080/01913123.2017.1300618. Epub 2017 Apr 4.
Mitochondria-associated membranes (MAMs) are currently considered an intracellular organelle "hot spot" for the intracellular signaling. MAMs are thought to function in cellular energy homeostasis, apoptosis, and calcium signaling. MAM ultrastructure in surgical specimens from human astrocytic neoplasms was studied. Abnormalities in respect to density, length, and width were found. Poorly differentiated glioma like-stem cells deficient in MAM and well-differentiated glioma cells abundant in MAM were observed. This finding could be the structural basis of functional role of MAM linked to some metabolic abnormalities in astrocytic tumors associated to mitochondrial dysfunction and the Warburg effect and their therapeutics implications.
线粒体相关膜（MAMs）目前被认为是细胞内信号传导的一个细胞内细胞器“热点”。MAMs被认为在细胞能量稳态、细胞凋亡和钙信号传导中发挥作用。对来自人类星形细胞瘤手术标本中的MAM超微结构进行了研究。发现了密度、长度和宽度方面的异常。观察到MAM缺乏的低分化胶质瘤样干细胞和MAM丰富的高分化胶质瘤细胞。这一发现可能是MAM功能作用的结构基础，与星形细胞瘤中一些与线粒体功能障碍和瓦伯格效应相关的代谢异常及其治疗意义有关。
