Gobba Naglaa Abd El Khalik, Hussein Ali Abdelmaksoud, El Sharawy Dalia E, Hussein Mohammed Abdalla
a Department of Pharmacology and Toxicology, College of Pharmacy , Misr University for Science and Technology (MUST) , 6th of October City , Egypt.
b Department of Biochemistry, Faculty of Veterinary Medicine , Benha University , Qalioubeya , Egypt.
Arch Environ Occup Health. 2018 May 4;73(3):189-202. doi: 10.1080/19338244.2017.1314930. Epub 2017 May 1.
Exposure to iron dust and welding fumes is widespread and may increase the risk of lung inflammation. The aim of this study was to identify associations between exposure to iron/welding fumes and the levels of inflammatory parameters and allergic mediators among 120 Egyptian men. Forty nonsmoking and 40 smoking Egyptian welders as well as 40 healthy volunteers who were never exposed to welding fumes and were nonsmoking were enrolled in the study. Peak expiratory flow rates (PEFR) assessed at the end of the shift of work on working days revealed an impairment in lung function, with the smoking workers showing the worse results, followed by nonsmoking workers, as compared to healthy volunteers. Moreover, the results of the present study showed a significant increase in serum iron and immunoglobulin E, as well as plasma thiobarbaturic acid reactive substances, C-reactive protein, tumor necrosis factor-alpha, haptoglobin, interleukin-2, interleukin-6 and interleukin-23 histamine, lactate dehydrogenase isoenzyme-3, and calcitonin. In addition, the results revealed significant decrease in plasma α-1-antitrypsin and serum transferrin, as well as blood activities of antioxidant enzymes: catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase (as compared with control group). However, there was a nonsignificant change in arginase and α-L-fucosidase in smoking and nonsmoking welders exposed to iron dust and welding fumes. In conclusion, occupational exposure to iron dust and welding fumes increases lung inflammation risk among Egyptian blacksmith workers, a condition that worsens with smoking.
接触铁尘和焊接烟雾的情况很普遍，可能会增加肺部炎症的风险。本研究的目的是确定120名埃及男性中接触铁/焊接烟雾与炎症参数和过敏介质水平之间的关联。40名不吸烟的埃及焊工、40名吸烟的埃及焊工以及40名从未接触过焊接烟雾且不吸烟的健康志愿者参与了该研究。工作日工作班次结束时评估的呼气峰值流速（PEFR）显示肺功能受损，与健康志愿者相比，吸烟工人的结果最差，其次是不吸烟工人。此外，本研究结果显示血清铁、免疫球蛋白E、血浆硫代巴比妥酸反应物质、C反应蛋白、肿瘤坏死因子-α、触珠蛋白、白细胞介素-2、白细胞介素-6和白细胞介素-23、组胺、乳酸脱氢酶同工酶-3以及降钙素显著增加。此外，结果显示血浆α-1-抗胰蛋白酶和血清转铁蛋白显著降低，以及抗氧化酶的血液活性：过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶（与对照组相比）。然而，接触铁尘和焊接烟雾的吸烟和不吸烟焊工的精氨酸酶和α-L-岩藻糖苷酶没有显著变化。总之，职业性接触铁尘和焊接烟雾会增加埃及铁匠工人的肺部炎症风险，这种情况在吸烟时会恶化。
