Haratake J, Horie A, Takeda S, Hisatomi K, Tokudome S
Dept. of Pathology & Oncology, Univ. of Occupational & Environmental Health.
Gan No Rinsho. 1988 May;34(6):759-63.
Seventy-five consecutive primary liver cancers that had a hepatic resection have been examined clinicopathologically. Eighteen were HBsAg+ cases (mean age: 50.9 yr) and 57 were HBsAg- cases (mean age 60.1 yr). HBsAg was not detected in the livers of the 57 HBsAg- cases, though it was found in the noncancerous parts of 16 of these cases and in the cancerous parts of 3 of the 18 HBsAg+ cases. A histologic, comparative study between the HBsAg+ and HBsAg+ cases showed no significant morphologic differences, except for somewhat frequent portal invasions in the former. From the viewpoint of prognosis, the ominous signs seem to be a positivity of serum HBsAg, large tumors, the presence of a portal and/or hepatic venous invasion, the presence of intra-and/or extrahepatic implants, and a high Edmondson's grade.
对75例接受肝切除的连续性原发性肝癌进行了临床病理检查。18例为HBsAg阳性病例（平均年龄：50.9岁），57例为HBsAg阴性病例（平均年龄60.1岁）。57例HBsAg阴性病例的肝脏中未检测到HBsAg，不过在其中16例的非癌部分以及18例HBsAg阳性病例中的3例癌部分检测到了HBsAg。对HBsAg阳性和阴性病例进行的组织学对比研究显示，除了前者门静脉侵犯稍常见外，无显著形态学差异。从预后角度来看，不良征象似乎包括血清HBsAg阳性、肿瘤较大、存在门静脉和/或肝静脉侵犯、存在肝内和/或肝外种植以及高Edmondson分级。
