Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95124 Catania, Italy.
Department of Epidemiology and Population Studies, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Nutrients. 2017 Aug 28;9(9):950. doi: 10.3390/nu9090950.
A meta-analysis was conducted to summarize the evidence from prospective cohort and case-control studies regarding the association between coffee intake and biliary tract cancer (BTC) and liver cancer risk.
Eligible studies were identified by searches of PubMed and EMBASE databases from the earliest available online indexing year to March 2017. The dose-response relationship was assessed by a restricted cubic spline model and multivariate random-effect meta-regression. A stratified and subgroup analysis by smoking status and hepatitis was performed to identify potential confounding factors.
We identified five studies on BTC risk and 13 on liver cancer risk eligible for meta-analysis. A linear dose-response meta-analysis did not show a significant association between coffee consumption and BTC risk. However, there was evidence of inverse correlation between coffee consumption and liver cancer risk. The association was consistent throughout the various potential confounding factors explored including smoking status, hepatitis, etc. Increasing coffee consumption by one cup per day was associated with a 15% reduction in liver cancer risk (RR 0.85; 95% CI 0.82 to 0.88).
The findings suggest that increased coffee consumption is associated with decreased risk of liver cancer, but not BTC.
对前瞻性队列研究和病例对照研究进行了荟萃分析，以总结有关咖啡摄入量与胆道癌（BTC）和肝癌风险之间关联的证据。
通过检索 PubMed 和 EMBASE 数据库，从最早的在线索引年份到 2017 年 3 月，确定了合格的研究。通过受限立方样条模型和多变量随机效应荟萃回归评估了剂量反应关系。通过分层和亚组分析吸烟状况和肝炎，以确定潜在的混杂因素。
我们确定了五项关于 BTC 风险的研究和 13 项关于肝癌风险的研究符合荟萃分析的条件。线性剂量反应荟萃分析显示，咖啡消费与 BTC 风险之间没有显著关联。然而，有证据表明咖啡消费与肝癌风险呈负相关。这种关联在包括吸烟状况、肝炎等各种潜在混杂因素的探索中是一致的。每天增加一杯咖啡与肝癌风险降低 15%相关（RR 0.85；95%CI 0.82 至 0.88）。
研究结果表明，增加咖啡的摄入量与降低肝癌的风险有关，但与 BTC 无关。
