Durg Sharanbasappa, B Naveen Kumar, Vandal Ravichandra, Dhadde Shivsharan B, Thippeswamy B S, Veerapur Veeresh P, Badami Shrishailappa
Sree Siddaganga College of Pharmacy, Tumkur 572102, Karnataka, India.
Sree Siddaganga College of Pharmacy, Tumkur 572102, Karnataka, India.
Biomed Pharmacother. 2017 Jun;90:328-331. doi: 10.1016/j.biopha.2017.03.085. Epub 2017 Apr 1.
Embelia ribes is claimed in Indian traditional medical practice to be useful in the treatment of nervous diseases. Embelin, an alkyl substituted hydroxy benzoquinone, is a major active constituent of E. ribes. The present preliminary study was intended to evaluate antipsychotic activity of embelin against apomorphine-induced climbing behaviour in mice and stereotyped behaviour in rats.
Two doses of embelin (5 and 10mg/kg) were administered once daily for 15days before exposure to apomorphine. On the concluding day of pre-treatment, after apomorphine-injection, the rodents were assessed for climbing and stereotyped behaviours according to the published scoring system. Thereafter, neurotransmitters (dopamine, noradrenaline and serotonin) levels were estimated in rodent brains.
Embelin pre-treatment significantly inhibited apomorphine-induced climbing and stereotyped behaviours in mice and rats, respectively. Further, embelin also statistically reversed elevated levels of dopamine, noradrenaline and serotonin neurotransmitters in the brain of mice and rats. Embelin showed more significant results at high dose (10mg/kg) than low dose (5mg/kg) in both the tested models.
Considering the present pharmacological profile of embelin, it is suggested that embelin possesses antipsychotic activity in the treatment of psychotic disorders. However, further research is warranted for evaluating its exact mechanism of action.
在印度传统医学实践中，紫金牛被认为可用于治疗神经系统疾病。紫金牛醌是一种烷基取代的羟基苯醌，是紫金牛的主要活性成分。本初步研究旨在评估紫金牛醌对阿扑吗啡诱导的小鼠攀爬行为和大鼠刻板行为的抗精神病活性。
在暴露于阿扑吗啡前，给予两种剂量的紫金牛醌（5和10mg/kg），每日一次，共15天。在预处理的最后一天，注射阿扑吗啡后，根据已发表的评分系统评估啮齿动物的攀爬和刻板行为。此后，测定啮齿动物大脑中的神经递质（多巴胺、去甲肾上腺素和5-羟色胺）水平。
紫金牛醌预处理分别显著抑制了阿扑吗啡诱导的小鼠和大鼠的攀爬及刻板行为。此外，紫金牛醌还在统计学上逆转了小鼠和大鼠大脑中多巴胺、去甲肾上腺素和5-羟色胺神经递质水平的升高。在两个测试模型中，高剂量（10mg/kg）的紫金牛醌比低剂量（5mg/kg）显示出更显著的结果。
考虑到紫金牛醌目前的药理学特性，提示紫金牛醌在治疗精神障碍方面具有抗精神病活性。然而，有必要进一步研究以评估其确切作用机制。
