Sree Siddaganga College of Pharmacy, Tumkur 572102, Karnataka, India.
Neurotox Res. 2011 Nov;20(4):379-86. doi: 10.1007/s12640-011-9258-7. Epub 2011 Jul 13.
Embelia ribes is being used in Indian traditional herbal medicine for the treatment of mental disorders and as brain tonic. The present study was designed to investigate the protective effects of embelin from E. ribes on global ischemia/reperfusion-induced brain injury in rats. Transient global ischemia was induced by occluding bilateral common carotid arteries for 30 min followed by 24-h reperfusion. Neurological functions were measured using sensorimotor tests. Ischemia/reperfusion-induced neuronal injury was assessed by cerebral infarct area, biochemical and histopathological examination. Pretreatment of embelin (25 and 50 mg/kg, p.o.) significantly increased locomotor activity and hanging latency time and decreased beam walking latency when compared with ischemic control. The treatment also reduced significantly the lipid peroxidation and increased the total thiol content and glutathione-S-transferase activity in brain homogenates. The decreased cerebral infarction area in embelin-treated groups and histopathological observations confirmed the above findings. These observations suggested that embelin is a neuroprotective agent and may prove to be useful adjunct in the treatment of stroke.
余甘子在印度传统草药医学中被用于治疗精神障碍和补脑。本研究旨在探讨余甘子中的安贝素对大鼠全脑缺血再灌注损伤的保护作用。通过阻断双侧颈总动脉 30 分钟来诱导短暂性全脑缺血，随后进行 24 小时再灌注。使用感觉运动测试来测量神经功能。通过脑梗死面积、生化和组织病理学检查评估缺血再灌注诱导的神经元损伤。与缺血对照相比，安贝素（25 和 50mg/kg，po）预处理显著增加了运动活性和悬挂潜伏期，同时减少了在平衡木上行走的潜伏期。该治疗还显著降低了脑匀浆中的脂质过氧化产物，增加了总巯基含量和谷胱甘肽-S-转移酶活性。在安贝素治疗组中，脑梗死面积减少，组织病理学观察结果证实了上述发现。这些观察结果表明，安贝素是一种神经保护剂，可作为治疗中风的辅助药物。
