Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Curr Opin Neurobiol. 2017 Aug;45:32-38. doi: 10.1016/j.conb.2017.03.001. Epub 2017 Apr 1.
AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent subcellular localization and gating of AMPARs. In this review we report about recent findings on the diversity of AMPAR complexes that allow us to better understand functional properties of native receptors in the brain.
AMPA 受体 (AMPAR) 复合物由四个 AMPAR 亚基 GluA1-4 和几个其他相互作用的蛋白组成。亚基组成决定了 AMPAR 的功能。然而，AMPAR 的功能在很大程度上也取决于相互作用的蛋白，这些蛋白影响 AMPAR 向细胞表面的运输、活性依赖性亚细胞定位和门控。在这篇综述中，我们报告了关于 AMPAR 复合物多样性的最新发现，这些发现使我们能够更好地理解大脑中天然受体的功能特性。
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