Stutzmann J M, Lucas M, Blanchard J C, Laduron P M
Rhôme Poulene Santé, Centre de Recherches de Vitry, Vitry sur Seine, France.
Neurosci Lett. 1988 May 26;88(2):195-200. doi: 10.1016/0304-3940(88)90125-5.
Riluzole is a drug that interferes with glutamate neurotransmitters. We studied the sleep pattern of rats treated orally with riluzole at doses ranging from 0.5 to 8 mg/kg. Duration of slow wave sleep and rapid eye movement sleep was found to increase in a dose-dependent manner from 1 mg/kg, at the expense of awakeness. These data suggest that glutamate neurotransmission may be involved in the regulation of sleep. Riluzole can be of interest as sleep modulator, in particular in psychiatric disorders.
利鲁唑是一种干扰谷氨酸神经递质的药物。我们研究了口服剂量为0.5至8毫克/千克的利鲁唑对大鼠睡眠模式的影响。发现从1毫克/千克起，慢波睡眠和快速眼动睡眠的时长以剂量依赖的方式增加，同时清醒时间减少。这些数据表明谷氨酸神经传递可能参与睡眠调节。利鲁唑作为一种睡眠调节剂可能会受到关注，尤其是在精神疾病方面。
