Sangiah S, Caldwell D F, Villeneuve M J, Clancy J J
Life Sci. 1982 Aug 23;31(8):763-9. doi: 10.1016/0024-3205(82)90702-0.
Administration of a single non-convulsive dose of insulin (1.0, I.U./kg., I.P.) which produced no observable gross behavioral changes in rats, reduced rapid eye movement (REM) sleep time 100% in the first 3 hrs. and 82% by the 4th hr., reaching control subject levels (saline-treated) by the 6th hr. In contrast, slow-wave sleep (NREM) time in insulin treated animals exceeded control subject levels by 49% by the end of the 2nd hr., returning to normal by the 5th hr. Although there was no difference between insulin and saline treated rats for the total 8 hr. post-injection recording period for total percentage of time awake, or slow-wave sleep time, a 44% reduction in REM sleep time was observed in insulin treated animals compared to that of a saline treated control. The significance of these findings are discussed in terms of known neurochemical changes i.e., an increase of both brain tryptophan and serotonin in rats, induced by a subconvulsive dose of exogenous insulin.
给大鼠腹腔注射单剂量非惊厥性胰岛素（1.0国际单位/千克），未观察到大鼠有明显的总体行为变化，在最初3小时内快速眼动（REM）睡眠时间减少了100%，到第4小时减少了82%，到第6小时恢复到对照（生理盐水处理）水平。相比之下，胰岛素处理动物的慢波睡眠（NREM）时间在第2小时末比对照水平高出49%，到第5小时恢复正常。虽然在注射后8小时的记录期内，胰岛素处理组和生理盐水处理组大鼠在清醒总时间百分比或慢波睡眠时间方面没有差异，但与生理盐水处理的对照组相比，胰岛素处理动物的REM睡眠时间减少了44%。根据已知的神经化学变化，即亚惊厥剂量的外源性胰岛素诱导大鼠脑内色氨酸和血清素均增加，对这些发现的意义进行了讨论。
