Yuan Si-Jie, Xie Hai-Ting, Li Zhong-Li
Department of Respiratory, Zhujiang Hospital , Southern Medical University, Guangzhou 510282, China.E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Mar 20;37(3):415-419. doi: 10.3969/j.issn.1673-4254.2017.03.25.
To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD).
Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group.
The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P<0.01) and fibrinogen (r=0.534, P<0.01).
Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.
探讨血浆超敏C反应蛋白（hs-CRP）、纤维蛋白原及D-二聚体（D-DI）水平在结缔组织病（CTD）相关间质性肺病（CTD-ILD）患者中的临床意义。
分析2010年1月至2016年4月在珠江医院住院的69例间质性肺病患者，其中29例为CTD-ILD患者，40例为非CTD-ILD患者，检测其血浆hs-CRP、纤维蛋白原及D-DI水平，并以25例健康受试者作为对照组。
CTD-ILD组和非CTD-ILD组患者的血浆hs-CRP、纤维蛋白原及D-DI水平均显著高于对照组。CTD-ILD组患者的hs-CRP水平显著高于非CTD-ILD组，但两组的纤维蛋白原及D-DI水平相当。相关性分析表明，hs-CRP水平与D-DI水平（r=0.539，P<0.01）及纤维蛋白原水平（r=0.534，P<0.01）呈正相关。
hs-CRP、纤维蛋白原及D-DI水平在CTD的临床诊断中具有重要价值，hs-CRP明显升高与CTD相关。
