Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China.
Aging (Albany NY). 2020 Mar 12;12(5):4371-4378. doi: 10.18632/aging.102890.
Vitamin D deficiency was associated with CTD-ILD and reduced lung function. We sought to confirm that lower Vitamin D level would be related to shorter survival times.
The CTD-ILD patients had lower Vitamin D level(P<0.05). Among patients with CTD-ILD who have improved lung function after treatment, elevation of Vitamin D level was positively associated with ΔFVC (%), ΔFEV1(%) and ΔDLCO-SB (%). The median survival time of patients with high serum 25(OH)D level was significantly longer than the patients with low 25(OH)D level group (16.5 months vs14.0 months, P=0.007). The Vitamin D was identified as an independent prognostic factor with a hazard ratio of 0.869 (95% CI 0.772-0.977, P =0.019).
Vitamin D level was lower in patients with CTD-ILD and associated with poor prognosis. Continuous levels of Vitamin D may be an important serum biomarker of prognosis.
85 CTD-ILD patients, 71 Idiopathic pulmonary fibrosis (IPF) patients and 78 healthy control patients were included in the study. In the subgroup analysis, the CTD-ILD patients were divided into anti-MDA5 antibody-positive group and anti-MDA5 antibody-negative group according to the serum autoantibodies results. The survival analysis evaluated effect of Vitamin D level on disease prognosis.
维生素 D 缺乏与结缔组织病相关间质性肺病（CTD-ILD）和肺功能下降有关。我们试图证实较低的维生素 D 水平与较短的生存时间有关。
CTD-ILD 患者的维生素 D 水平较低（P<0.05）。在 CTD-ILD 患者中，治疗后肺功能改善的患者中，维生素 D 水平升高与 ΔFVC（%）、ΔFEV1（%）和 ΔDLCO-SB（%）呈正相关。高血清 25（OH）D 水平患者的中位生存时间明显长于低 25（OH）D 水平组（16.5 个月比 14.0 个月，P=0.007）。维生素 D 被确定为独立的预后因素，风险比为 0.869（95%CI 0.772-0.977，P=0.019）。
CTD-ILD 患者的维生素 D 水平较低，与预后不良相关。维生素 D 的持续水平可能是预后的重要血清生物标志物。
纳入 85 例 CTD-ILD 患者、71 例特发性肺纤维化（IPF）患者和 78 例健康对照组患者进行研究。在亚组分析中，根据血清自身抗体结果，将 CTD-ILD 患者分为抗 MDA5 抗体阳性组和抗 MDA5 抗体阴性组。生存分析评估了维生素 D 水平对疾病预后的影响。
