Barsdorf Alexandra I, Carlsson Martin, Bushmakin Andrew G, Quinn Sheila, Cappelleri Joseph C, Pleil Andreas
Outcomes & Evidence, Global Health & Value Pfizer Inc, 235 East 42nd Street, New York, NY, 10017, USA.
Pfizer Inc, Groton, CT, USA.
Int Urogynecol J. 2017 Dec;28(12):1857-1863. doi: 10.1007/s00192-017-3305-8. Epub 2017 Apr 4.
The 33-item Overactive Bladder questionnaire (OAB-q; 1-week recall version) has been psychometrically validated in middle-aged, generally healthy patients with overactive bladder. The present analysis was conducted to determine the psychometric validity of the OAB-q in medically complex elderly patients.
OAB-q structure was evaluated using a second-order confirmatory factor analysis (CFA) model with five domains and one aggregated domain, using pooled data from two clinical trials (786 observations) for urgency urinary incontinence (UUI). Psychometric validity was evaluated with CFA, Cronbach coefficient α (CCA) for reliability, Spearman correlations for convergent validity, differences in OAB-q scores in relation to UUI severity and Patient Perception of Bladder Condition (PPBC) scores for known-groups validity, and effect size (ES) of differences in mean scores of OAB-q domains over time for treatment responsiveness.
Participants were predominantly female (82.2%) and white (85.9%); mean age was 75.0 years. The second-order CFA was confirmed with a Bentler's comparative fit index of 0.90, t values for path coefficients of >1.96, and standardized path coefficients of >0.40. OAB-q domains demonstrated good internal consistency (CCA >0.7). Convergent validity was supported by moderate correlations (0.4-0.7) between OAB-q domain and PPBC scores. Significant differences in OAB-q domain scores between groups with different symptom severity established known-groups validity. Significant changes in mean OAB-q scores from baseline to week 12 with moderate-to-large ES (0.50-0.80) demonstrated treatment responsiveness.
The OAB-q demonstrates reliability, concurrent and discriminant validity, and responsiveness to treatment. The evidence shows that the OAB-q is psychometrically sound for use in medically complex elderly patients with overactive bladder.
33项膀胱过度活动症问卷（OAB-q；1周回忆版）已在患有膀胱过度活动症的中年、一般健康患者中进行了心理测量学验证。本分析旨在确定OAB-q在患有多种疾病的老年患者中的心理测量学有效性。
使用二阶验证性因子分析（CFA）模型评估OAB-q结构，该模型有五个领域和一个汇总领域，使用来自两项关于急迫性尿失禁（UUI）的临床试验（786次观察）的汇总数据。通过CFA评估心理测量学有效性，用Cronbach系数α（CCA）评估可靠性，用Spearman相关性评估收敛效度，根据UUI严重程度评估OAB-q得分差异以及根据已知群体效度评估膀胱状况患者感知（PPBC）得分，并用OAB-q领域平均得分随时间变化的效应量（ES）评估治疗反应性。
参与者主要为女性（82.2%）和白人（85.9%）；平均年龄为75.0岁。二阶CFA得到确认，Bentler比较拟合指数为0.90，路径系数的t值>1.96，标准化路径系数>0.40。OAB-q领域显示出良好的内部一致性（CCA>0.7）。OAB-q领域与PPBC得分之间的中度相关性（0.4 - 0.7）支持了收敛效度。不同症状严重程度组之间OAB-q领域得分的显著差异确立了已知群体效度。从基线到第12周，OAB-q平均得分有显著变化，效应量为中度至较大（0.50 - 0.80），表明有治疗反应性。
OAB-q显示出可靠性、同时效度和区分效度以及对治疗的反应性。证据表明，OAB-q在心理测量学上适用于患有多种疾病的老年膀胱过度活动症患者。
