Department of Urology, Hospital Universitari I Politecnic La Fe, Valencia, Spain.
Clin Drug Investig. 2012 Aug 1;32(8):523-32. doi: 10.2165/11633760-000000000-00000.
Overactive bladder (OAB) is characterized by the symptoms of urinary urgency or urge incontinence, which appear without a local pathological or metabolic explanation. OAB is defined by symptoms and the evaluation of treatment effectiveness should be based upon patient perceptions. The Overactive Bladder Questionnaire-Short Form (OAB-q SF) is a brief, self-administered patient-reported outcomes tool with two scales assessing symptom bother and health-related quality of life (HR-QOL) in patients with OAB.
This study aimed to adapt the OAB-q SF into Spanish and to estimate its psychometric properties in patients with symptomatic overactive bladder.
The Spanish version of the OAB-q SF was administered on two occasions, 3 months apart, to a set of patients of both sexes, over 18 years of age, diagnosed with OAB, scoring ≥8 on the OAB-V8 scale (a self-reported 8-item OAB screening and awareness tool), and able to understand patient-reported-outcome instruments written in Spanish. Patients were recruited consecutively at urology clinics. Feasibility, internal consistency (Cronbach's alpha), test-retest reliability, structure of instrument, criteria and construct validity and responsiveness were examined using classic test theory statistics.
Data from 246 OAB patients (mean age 57.7 years, 76% women, 99% Caucasian, 37% workers and 36% with a primary education) were evaluated. Floor and ceiling effects ranged between 0.8% and 33%, and missing items were below 2%. Cronbach's alphas attained 0.811 and 0.922 for symptom-bother and HR-QOL domains, respectively. These two subscales matched the original structure and explained variances above 50%, which correlated moderately with EQ-5D (EuroQol) [r = -0.28 and r = +0.31, respectively (p < 0.001 in both cases)]. A significant change in OAB-q SF mean domain scores (-23.8; 95% CI -26.3, -21.3; and +17.7; 95% CI 15.4, 20.6; p < 0.001 in both cases; [effect sizes: 1.32 and 0.98]) was observed after 3 months of medical treatment.
The Spanish version of the OAB-q SF demonstrated sufficiently strong psychometric properties of reliability, validity and responsiveness to be used in the measurement of OAB symptom severity and HR-QOL.
膀胱过度活动症（OAB）的特征是出现尿急或急迫性尿失禁症状，而无局部病理或代谢原因。OAB 由症状定义，治疗效果的评估应基于患者的感知。OAB 问卷-短表（OAB-q SF）是一种简短的、自我管理的患者报告结果工具，有两个量表评估 OAB 患者的症状困扰和健康相关生活质量（HR-QOL）。
本研究旨在将 OAB-q SF 改编为西班牙语，并评估其在有症状的膀胱过度活动症患者中的心理测量特性。
在 3 个月的时间里，对一组年龄在 18 岁及以上、OAB 诊断为 OAB 的男女患者进行了 OAB-q SF 的西班牙语版本的两次评估，OAB-V8 量表评分≥8（一种自我报告的 8 项 OAB 筛查和意识工具），并且能够理解用西班牙语书写的患者报告结果工具。患者连续在泌尿科诊所招募。使用经典测试理论统计数据检查了可行性、内部一致性（克朗巴赫 α）、重测信度、仪器结构、标准和构念效度以及反应性。
对 246 名 OAB 患者（平均年龄 57.7 岁，76%为女性，99%为白种人，37%为工人，36%为小学教育）的数据进行了评估。地板和天花板效应在 0.8%至 33%之间，缺失项目低于 2%。症状困扰和 HR-QOL 两个分量表的克朗巴赫 α分别为 0.811 和 0.922。这两个分量表与原始结构相匹配，解释方差超过 50%，与 EQ-5D（EuroQol）中度相关[r=-0.28 和 r=+0.31，分别（p<0.001）]。经过 3 个月的药物治疗，OAB-q SF 平均领域评分（-23.8；95%CI-26.3，-21.3；+17.7；95%CI15.4，20.6；p<0.001；效应大小：1.32 和 0.98））有显著变化。
OAB-q SF 的西班牙语版本表现出足够强的可靠性、有效性和反应性心理测量特性，可用于测量 OAB 症状严重程度和 HR-QOL。
