Kasturi L, Sawant Sangeeta P
Department of Pediatrics, Bhabha Atomic Research Centre Hospital, Anushaktinagar, 400 094, Mumbai, Maharashtra, India.
Indian J Pediatr. 2005 Mar;72(3):243-244. doi: 10.1007/BF02859266.
The authors report a case of skeletal myopathy in a four-year-old boy on long-term sodium valproate therapy for secondary epilepsy due to neurocysticercosis. He presented with clinical features of limb girdle weakness. EMG revealed features of myopathy. Carnitine deficiency due to sodium valproate was suspected and plasma carnitine levels were found to be low. Sodium valproate was withdrawn. L-carnitine supplementation resulted in marked clinical recovery as well as rise in plasma carnitine levels.
作者报告了一例4岁男孩的骨骼肌病病例，该男孩因神经囊尾蚴病继发癫痫而长期接受丙戊酸钠治疗。他表现出肩胛带和骨盆带肌无力的临床特征。肌电图显示有肌病特征。怀疑是丙戊酸钠导致的肉碱缺乏，检测发现血浆肉碱水平较低。停用丙戊酸钠。补充左旋肉碱后，临床症状明显改善，血浆肉碱水平也有所上升。
