Joeris T, Müller-Luda K, Agace W W, Mowat A McI
Section of Immunology and Vaccinology, Danish Technical University Veterinary Institute, Copenhagen, Denmark.
Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Mucosal Immunol. 2017 Jul;10(4):845-864. doi: 10.1038/mi.2017.22. Epub 2017 Apr 5.
The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for 'fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.
肠道固有层（LP）包含多种单核吞噬细胞（MNP）亚群，包括传统树突状细胞（cDC）、单核细胞和组织驻留巨噬细胞（mφ），它们共同在黏膜稳态、感染和炎症中发挥重要作用。在本综述中，我们讨论肠道cDC和单核细胞衍生的MNP的功能，强调这些亚群如何在肠道免疫反应调节中发挥多种非冗余作用。尽管仍有许多有待了解，但最近的研究结果也突显了MNP的不同群体如何适应应对其特定环境所带来的挑战。了解这些过程应有助于针对各个亚群对肠道内的免疫反应进行“微调”，这一过程可能与炎症性肠病（IBD）的治疗以及优化疫苗设计都相关。
