Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Immunol Cell Biol. 2013 Mar;91(3):232-9. doi: 10.1038/icb.2012.79. Epub 2013 Feb 12.
Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+) dendritic cells and CX3CR1(+) macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).
肠道单核吞噬细胞作为维持肠道内环境稳态、肠道炎症发生和消退的关键因素而集体出现。此外，许多实验室最近的深入研究揭示了固有层驻留的 CD103(+)树突状细胞和 CX3CR1(+)巨噬细胞之间关键分工的证据。深入了解这些细胞在黏膜景观中的各自活性可能为炎症性肠病（IBD）的新治疗方法铺平道路。
